| Literature DB >> 10581427 |
V Ferranti1, H Marchais, C Chabenat, A M Orecchioni, O Lafont.
Abstract
This paper describes the preparation of primidone-loaded poly-epsilon-caprolactone nanocapsules according to the interfacial deposition technique. The colloidal suspension obtained showed a monomodal size distribution with a mean diameter ranging from 308 to 352 nm. By adjusting the process parameters, the encapsulation efficiency was about 74% with good reproducibility. Primidone release from the nanocapsules was found to be slower as compared to the oily control solution despite an important burst-effect. The release profile was not influenced by the pH of the release medium.Entities:
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Year: 1999 PMID： 10581427 DOI： 10.1016/s0378-5173(99)00325-7
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875