Literature DB >> 10580644

A side-reaction in the SPPS of Trp-containing peptides.

M Giraud1, F Cavelier, J Martinez.   

Abstract

Syntheses of several Trp-containing peptides on a Wang solid support afforded significant amounts of a side-product. 1H-NMR and MS data showed that an unexpected alkylation by the linker has occurred on the indole nucleus. This was observed whatever the scavenger used, and whatever the position of the Trp residue in the sequence, unless it was in the C-terminal position.

Entities:  

Mesh:

Substances:

Year:  1999        PMID: 10580644     DOI: 10.1002/(SICI)1099-1387(199910)5:10<457::AID-PSC215>3.0.CO;2-7

Source DB:  PubMed          Journal:  J Pept Sci        ISSN: 1075-2617            Impact factor:   1.905


  1 in total

1.  1,4-Benzenedimethanethiol (1,4-BDMT) as a scavenger for greener peptide resin cleavages.

Authors:  Jan Pawlas; Thomas Svensson; Jon H Rasmussen
Journal:  RSC Adv       Date:  2019-11-28       Impact factor: 3.361

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.