Literature DB >> 10580191

The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice.

M Naito1, M Matsuoka, N Ohara, H Nomaguchi, T Yamada.   

Abstract

The proteins in culture filtrate derived from Bacillus Calmette-Guérin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon gamma (IFNgamma) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection.

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Year:  1999        PMID： 10580191     DOI： 10.1016/s0264-410x(99)00327-8

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  6 in total

1.  Enoyl-coenzyme A hydratase and antigen 85B of Mycobacterium habana are specifically recognized by antibodies in sera from leprosy patients.

Authors:  J Serafín-López; M Talavera-Paulin; J C Amador-Molina; M Alvarado-Riverón; M M Vilchis-Landeros; P Méndez-Ortega; M Fafutis-Morris; V Paredes-Cervantes; R López-Santiago; C I León; M I Guerrero; R M Ribas-Aparicio; G Mendoza-Hernández; C Carreño-Martínez; S Estrada-Parra; I Estrada-García
Journal:  Clin Vaccine Immunol       Date:  2011-05-25

2.  In vitro cellular immune responses to recombinant antigens of Mycobacterium avium subsp. paratuberculosis.

Authors:  Sung Jae Shin; Chao-Fu Chang; Ching-Dong Chang; Sean P McDonough; Belinda Thompson; Han Sang Yoo; Yung-Fu Chang
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

Review 3.  Advances and hurdles on the way toward a leprosy vaccine.

Authors:  Malcolm S Duthie; Thomas P Gillis; Steven G Reed
Journal:  Hum Vaccin       Date:  2011-11-01

4.  The domains of human fibronectin mediating the binding of alpha antigen, the most immunopotent antigen of mycobacteria that induces protective immunity against mycobacterial infection.

Authors:  M Naito; T Fukuda; K Sekiguchi; T Yamada
Journal:  Biochem J       Date:  2000-05-01       Impact factor: 3.857

5.  Pathogenesis and Host Immune Response in Leprosy.

Authors:  Hadida Yasmin; Praveen Mathews Varghese; Sanjib Bhakta; Uday Kishore
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 6.  Combination chemoprophylaxis and immunoprophylaxis in reducing the incidence of leprosy.

Authors:  Malcolm S Duthie; Marivic F Balagon
Journal:  Risk Manag Healthc Policy       Date:  2016-04-27
  6 in total

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