Literature DB >> 10580047

Free thiol groups are essential for infectivity of human cytomegalovirus.

Ali Mirazimi1, Mehrdad Mousavi-Jazi1, Vivi-Anne Sundqvist2, Lennart Svensson1.   

Abstract

The membrane-impermeable thiol blocker 5'5-dithiobis 2- nitrobenzoic acid (DTNB) blocked infectivity of human cytomegalovirus (CMV) although the virus still bound to cells. DTNB-treated CMV regained 65% of its infectivity after incubation with the disulfide bond-reducing agent dithiothreitol. These observations suggest that free thiol groups on CMV are required for infectivity and may participate in disulfide bond formation during virus entry.

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Year:  1999        PMID： 10580047     DOI： 10.1099/0022-1317-80-11-2861

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  4 in total

1.  Disulfide Sensitivity in the Env Protein Underlies Lytic Inactivation of HIV-1 by Peptide Triazole Thiols.

Authors:  Lauren D Bailey; Ramalingam Venkat Kalyana Sundaram; Huiyuan Li; Caitlin Duffy; Rachna Aneja; Arangassery Rosemary Bastian; Andrew P Holmes; Kantharaju Kamanna; Adel A Rashad; Irwin Chaiken
Journal:  ACS Chem Biol       Date:  2015-10-22       Impact factor: 5.100

2.  Specific inhibition of human cytomegalovirus glycoprotein B-mediated fusion by a novel thiourea small molecule.

Authors:  Thomas R Jones; Shi-Wu Lee; Stephen V Johann; Vladimir Razinkov; Robert J Visalli; Boris Feld; Jonathan D Bloom; John O'Connell
Journal:  J Virol       Date:  2004-02       Impact factor: 5.103

3.  Formation of disulfide-linked complexes between the three minor envelope glycoproteins (GP2b, GP3, and GP4) of equine arteritis virus.

Authors:  Roeland Wieringa; Antoine A F de Vries; Peter J M Rottier
Journal:  J Virol       Date:  2003-06       Impact factor: 5.103

4.  Nanobubble Ozone Stored in Hyaluronic Acid Decorated Liposomes: Antibacterial, Anti-SARS-CoV-2 Effect and Biocompatibility Tests.

Authors:  Ahmet Umit Sabancı; Perihan Erkan Alkan; Cem Mujde; Hivda Ulbeği Polat; Cemre Ornek Erguzeloglu; Atil Bisgin; Cuneyt Ozakin; Sehime G Temel
Journal:  Int J Nanomedicine       Date:  2022-01-25
  4 in total

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