Literature DB >> 10579811

Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists.

P G Baraldi1, B Cacciari, R Romagnoli, G Spalluto, K N Klotz, E Leung, K Varani, S Gessi, S Merighi, P A Borea.   

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Year:  1999        PMID： 10579811     DOI： 10.1021/jm991114s

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  13 in total

1.  Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell line.

Authors:  S Merighi; K Varani; S Gessi; E Cattabriga; V Iannotta; C Ulouglu; E Leung; P A Borea
Journal:  Br J Pharmacol       Date:  2001-11       Impact factor: 8.739

2.  Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells.

Authors:  S Gessi; K Varani; S Merighi; A Morelli; D Ferrari; E Leung; P G Baraldi; G Spalluto; P A Borea
Journal:  Br J Pharmacol       Date:  2001-09       Impact factor: 8.739

3.  Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility.

Authors:  Stephanie Federico; Silvia Paoletta; Siew Lee Cheong; Giorgia Pastorin; Barbara Cacciari; Stefano Stragliotto; Karl Norbert Klotz; Jeffrey Siegel; Zhan-Guo Gao; Kenneth A Jacobson; Stefano Moro; Giampiero Spalluto
Journal:  J Med Chem       Date:  2011-01-07       Impact factor: 7.446

Review 4.  A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.

Authors:  Kenneth A Jacobson; Stefania Merighi; Katia Varani; Pier Andrea Borea; Stefania Baraldi; Mojgan Aghazadeh Tabrizi; Romeo Romagnoli; Pier Giovanni Baraldi; Antonella Ciancetta; Dilip K Tosh; Zhan-Guo Gao; Stefania Gessi
Journal:  Med Res Rev       Date:  2017-07-06       Impact factor: 12.944

5.  Polypharmacology of N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential.

Authors:  Jinha Yu; Seyeon Ahn; Hee Jin Kim; Moonyoung Lee; Sungjin Ahn; Jungmin Kim; Sun Hee Jin; Eunyoung Lee; Gyudong Kim; Jae Hoon Cheong; Kenneth A Jacobson; Lak Shin Jeong; Minsoo Noh
Journal:  J Med Chem       Date:  2017-08-28       Impact factor: 7.446

6.  Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process.

Authors:  Giorgia Pastorin; Stephanie Federico; Silvia Paoletta; Marta Corradino; Francesca Cateni; Barbara Cacciari; Karl-Norbert Klotz; Zhan-Guo Gao; Kenneth A Jacobson; Giampiero Spalluto; Stefano Moro
Journal:  Bioorg Med Chem       Date:  2010-02-25       Impact factor: 3.641

7.  Pharmacological characterization of DPTN and other selective A3 adenosine receptor antagonists.

Authors:  Zhan-Guo Gao; R Rama Suresh; Kenneth A Jacobson
Journal:  Purinergic Signal       Date:  2021-10-28       Impact factor: 3.765

8.  9-Ethyladenine derivatives as adenosine receptor antagonists: 2- and 8-substitution results in distinct selectivities.

Authors:  Karl-Norbert Klotz; Sonja Kachler; Catia Lambertucci; Sauro Vittori; Rosaria Volpini; Gloria Cristalli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-05-07       Impact factor: 3.000

9.  Conjugable A3 adenosine receptor antagonists for the development of functionalized ligands and their use in fluorescent probes.

Authors:  Stephanie Federico; Enrico Margiotta; Stefano Moro; Eszter Kozma; Zhan-Guo Gao; Kenneth A Jacobson; Giampiero Spalluto
Journal:  Eur J Med Chem       Date:  2019-11-22       Impact factor: 6.514

10.  Potent and selective A3 adenosine receptor antagonists bearing aminoesters as heterobifunctional moieties.

Authors:  Stephanie Federico; Enrico Margiotta; Stefano Moro; Sonja Kachler; Karl-Norbert Klotz; Giampiero Spalluto
Journal:  RSC Med Chem       Date:  2020-12-14
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