Treatment of the growing pedicle with retinoic acid increased the size of the first antlers in fallow deer (Dama dama L.).

Unilateral injection of 10 mg of all-trans retinoic acid (RA) into the lateral portion of the growing pedicle of fallow bucks (n = 20) led to a significant (P = 0.033, Wilcoxon matched-pairs test) increase in first antler volume (median, 25.5 ml) as compared to the contralateral (control) side, injected with vehicle only (median, 21.5 ml). It is hypothesized that the RA treatment of the developing pedicle exercised a direct or indirect effect on the periosteal/perichondrial cells covering the growing cranial appendage, resulting in an increased proliferation rate of the cells of the antler perichondrium.