[Third generation of plasminogen activators. New directions in research].

Recent information on the development of new plasminogen activators (PA) is reviewed. The results of studies of PA mutant derivatives synthesized by recombinant DNA techniques are discussed. Data on chimeric (hybrid) forms of PAs and their chemically synthesized conjugates are presented. The trends in the search for PAs are analyzed. A new direction in the study of third-generation PAs for combined plasminogen activation and in the further development of the methods of thrombolytic therapy is outlined.