B E Klein1, R Klein, S E Moss. 1. Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705-2397, USA. kleinb@epi.ophth.wisc.edu
Abstract
PURPOSE: To quantitate the relationships of total cholesterol and high-density lipoprotein cholesterol to the incidence and progression of diabetic retinopathy and macular edema 5 years later in those with younger-onset diabetes of long duration. METHODS: Casual serum specimens for lipid values and fundus photography at the time of the lipid determinations were evaluated with regard to retinal lesions in photographs taken 5 years later during the course of a population-based cohort study. RESULTS: Univariable associations were significant for associations of incident retinal lesions with total cholesterol/high-density lipoprotein cholesterol, but multivariable associations considering covariates were not significant. CONCLUSION: Our data suggest that lowering cholesterol by therapeutic means may not be indicated for the sole purpose of decreasing the incidence or progression of these retinal lesions.
PURPOSE: To quantitate the relationships of total cholesterol and high-density lipoprotein cholesterol to the incidence and progression of diabetic retinopathy and macular edema 5 years later in those with younger-onset diabetes of long duration. METHODS: Casual serum specimens for lipid values and fundus photography at the time of the lipid determinations were evaluated with regard to retinal lesions in photographs taken 5 years later during the course of a population-based cohort study. RESULTS: Univariable associations were significant for associations of incident retinal lesions with total cholesterol/high-density lipoprotein cholesterol, but multivariable associations considering covariates were not significant. CONCLUSION: Our data suggest that lowering cholesterol by therapeutic means may not be indicated for the sole purpose of decreasing the incidence or progression of these retinal lesions.
Authors: Sandra S Hammer; Eleni Beli; Nermin Kady; Qi Wang; Kiana Wood; Todd A Lydic; Goldis Malek; Daniel R Saban; Xiaoxin X Wang; Sugata Hazra; Moshe Levi; Julia V Busik; Maria B Grant Journal: EBioMedicine Date: 2017-07-11 Impact factor: 8.143
Authors: Neil T Raymond; Lakshminarayanan Varadhan; Dilini R Reynold; Kate Bush; Sailesh Sankaranarayanan; Srikanth Bellary; Anthony H Barnett; Sudhesh Kumar; J Paul O'Hare Journal: Diabetes Care Date: 2008-12-15 Impact factor: 19.112