| Literature DB >> 10576693 |
M L Greenlee1, J B Laub, G P Rouen, F DiNinno, M L Hammond, J L Huber, J G Sundelof, G G Hammond.
Abstract
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-beta-methyl substituent was found to improve pharmacokinetics.Entities:
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Year: 1999 PMID： 10576693 DOI： 10.1016/s0960-894x(99)00567-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823