Literature DB >> 10576692

Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVA).

M Patel1, R J McHugh, B C Cordova, R M Klabe, S Erickson-Viitanen, G L Trainor, S S Ko.   

Abstract

Two series of benzoxazinones differing in the aromatic substitution pattern were prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The 5-fluoro (5a-d) and 6-nitro (5e-h) substituted compounds displayed activity comparable or better than Efavirenz, the lead structure of the series.

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Year:  1999        PMID： 10576692     DOI： 10.1016/s0960-894x(99)00565-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  A highly sensitive ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human seminal and blood plasma.

Authors:  Lindsay B Avery; Teresa L Parsons; David J Meyers; Walter C Hubbard
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2010-10-08       Impact factor: 3.205

2.  High-performance liquid chromatographic enantioseparation of Betti base analogs on a newly developed isopropyl carbamate-cyclofructan6-based chiral stationary phase.

Authors:  Anita Aranyi; István Ilisz; Zoltán Pataj; István Szatmári; Ferenc Fülöp; Daniel W Armstrong; Antal Péter
Journal:  Chirality       Date:  2011-06-16       Impact factor: 2.437

3.  1-Phenyl-1H-naphtho-[1,2-e][1,3]oxazin-3(2H)-one.

Authors:  Humaira Y Gondal; Misbah Bhatti; Azra Gohar; Muhammad Ali; M Nawaz Tahir
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-09-11

Review 4.  Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors.

Authors:  Valeria Famiglini; Romano Silvestri
Journal:  Antivir Chem Chemother       Date:  2018 Jan-Dec

5.  Design and syntheses of 7-nitro-2-aryl-4H-benzo[d][1,3]oxazin-4-ones as potent anticancer and antioxidant agents.

Authors:  Ayesha Bari; Zulfiqar Ali Khan; Sohail Anjum Shahzad; Syed Ali Raza Naqvi; Shakeel Ahmad Khan; Hira Amjad; Ahsan Iqbal; Muhammad Yar
Journal:  J Mol Struct       Date:  2020-04-13       Impact factor: 3.196
  5 in total

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