Literature DB >> 10576684

A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.

C S Li1, W C Black, C Brideau, C C Chan, S Charleson, W A Cromlish, D Claveau, J Y Gauthier, R Gordon, G Greig, E Grimm, J Guay, C K Lau, D Riendeau, M Thérien, D M Visco, E Wong, L Xu, P Prasit.   

Abstract

By inserting an oxygen link between the 3-fluorophenyl and the lactone ring of 5,5-dimethyl-3-(3fluorophenyl)-4-(4-methanesulfonylphenyl)-2 (5H)-furanone 1 (DFU), analogs with enhanced in vitro COX-2 inhibitory potency as well as in vivo potency in models of inflammation were obtained.

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Year:  1999        PMID： 10576684     DOI： 10.1016/s0960-894x(99)00559-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury.

Authors:  Jonas J Gopez; Hongfei Yue; Ram Vasudevan; Amir S Malik; Lester N Fogelsanger; Shawn Lewis; David Panikashvili; Esther Shohami; Susan A Jansen; Raj K Narayan; Kenneth I Strauss
Journal:  Neurosurgery       Date:  2005-03       Impact factor: 4.654

2.  Effects of Cyclooxygenase Inhibitors on Apoptotic Neuroretinal Cells.

Authors:  Anja-Kristina Brust; Holger K Ulbrich; Gail M Seigel; Norbert Pfeiffer; Franz H Grus
Journal:  Biomark Insights       Date:  2008-07-08

3.  Design, synthesis, molecular modeling and biological evaluation of novel diaryl heterocyclic analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors.

Authors:  Deema A Al-Turki; Mohamed A Al-Omar; Laila A Abou-Zeid; Ihsan A Shehata; Mohammed S Al-Awady
Journal:  Saudi Pharm J       Date:  2015-07-26       Impact factor: 4.330
  3 in total

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