| Literature DB >> 10576439 |
T Ravingerová1, J Slezák, N Tribulová, A Dzurba, B Uhrík, A Ziegelhöffer.
Abstract
Early period of reperfusion of ischemic myocardium is associated with a high incidence of severe tachyarrhythmias including ventricular tachycardia and fibrillation (VT and VF). Free oxygen radicals (FOR) have been identified as one of the principal factors responsible for reperfusion-induced events. However, their role in arrhythmogenesis is not clear. In the present study, in isolated Langendorff-perfused rat hearts subjected to 30 min global ischemia, the onset of reperfusion induced 100% incidence of both VT and VF with their gradual cessation over 5 min of reperfusion. Generation of H2O2 in the myocardium in the first minutes of reperfusion was visualized by means of cerium cytochemistry and confirmed by X-ray microanalysis. The mechanism of the arrhythmogenic effect of FOR may involve inhibition of the sarcolemmal Na+/K+-ATPase, as demonstrated in the rat heart sarcolemmal fraction subjected to FOR-generating system (H2O2 + FeSO4).Entities:
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Year: 1999 PMID： 10576439 DOI： 10.1016/s0024-3205(99)00449-x
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037