| Literature DB >> 10575910 |
G Wolf1.
Abstract
The glucocorticoid dexamethasone (dex) stimulates differentiation of cultured preadipocytes of the 3T3-L1 cell line to adipocytes. The preadipocytes express a gene termed preadipocyte factor 1 (pref-1). The pref-1 gene product is abundant in preadipocytes but completely absent in adipocytes. Constitutive expression of pref-1 blocks differentiation of adipocytes, as does a soluble 50 kDa fragment of the pref-1 protein. It appears that dex mediates adipogenesis by down-regulating expression of pref-1.Entities:
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Year: 1999 PMID： 10575910 DOI： 10.1111/j.1753-4887.1999.tb06907.x
Source DB: PubMed Journal: Nutr Rev ISSN： 0029-6643 Impact factor: 7.110