From yeast to man--from mitochondria to liver regeneration: a new essential gene family.

The purpose of this review is to bring to the attention of the reader the latest developments in research on an important new emerging gene family. The respective genes are found in eukaryotes from yeast to man and even on the genome of some doubled-stranded DNA viruses. They have essential functions in the biogenesis of mitochondria, the cell division cycle and, in higher eukaryotes, in the development of organs like liver and testis. The most important medical implication is their probable role in liver regeneration that will, therefore, be addressed in detail. Aspects of molecular biology, medical implications and problems of developmental biology reflect the complexity of the functions of these proteins and the subjects of the respective research. This is just the beginning of an interdisciplinary effort directed towards the elucidation of the precise function of these essential factors inside the eukaryotic cell. In the general part of this review, we will concentrate on the history of the discovery of these genes and on a summary of their characteristic features. In the more specialized section, the specific role as augmenter of liver regeneration will be addressed in detail.