H Yato1, Y Matsumoto. 1. Department of Ophthalmology, Nagoya University School of Medicine, Japan.
Abstract
AIMS: Natural killer T (NKT) cells, T lymphocytes expressing both T cell and NK cell markers, are suggested to be involved in autoimmune diseases. To examine the relation between the pathogenesis of uveitis and CD56+ T cells, which are thought to be a type of human NKT cells, we investigated peripheral CD56+ T cells in uveitis patients. METHODS: 41 uveitis patients (Behçet's disease (BD), 14; sarcoidosis (SAR), eight; Vogt-Koyanagi-Harada disease (VKH), five; idiopathic uveitis (IU), nine; and others, five) and 19 healthy controls participated in this study. Cell surface antigens of lymphocytes were analysed by use of monoclonal antibodies and flow cytometry. RESULTS: The proportion of CD56+ T cells in patients with BD was higher than in controls and in patients with SAR, VKH, IU, and others. CONCLUSION: Increased peripheral CD56+ T cells might be relevant to the pathogenesis of uveitis in BD, and increase of peripheral CD56+ T cells may be one of the laboratory findings to suggest that uveitis originates from BD.
AIMS: Natural killer T (NKT) cells, T lymphocytes expressing both T cell and NK cell markers, are suggested to be involved in autoimmune diseases. To examine the relation between the pathogenesis of uveitis and CD56+ T cells, which are thought to be a type of human NKT cells, we investigated peripheral CD56+ T cells in uveitispatients. METHODS: 41 uveitispatients (Behçet's disease (BD), 14; sarcoidosis (SAR), eight; Vogt-Koyanagi-Harada disease (VKH), five; idiopathic uveitis (IU), nine; and others, five) and 19 healthy controls participated in this study. Cell surface antigens of lymphocytes were analysed by use of monoclonal antibodies and flow cytometry. RESULTS: The proportion of CD56+ T cells in patients with BD was higher than in controls and in patients with SAR, VKH, IU, and others. CONCLUSION: Increased peripheral CD56+ T cells might be relevant to the pathogenesis of uveitis in BD, and increase of peripheral CD56+ T cells may be one of the laboratory findings to suggest that uveitis originates from BD.
Authors: C Miyaji; H Watanabe; M Minagawa; H Toma; T Kawamura; Y Nohara; H Nozaki; Y Sato; T Abo Journal: J Clin Immunol Date: 1997-09 Impact factor: 8.317
Authors: A Hasan; F Fortune; A Wilson; K Warr; T Shinnick; Y Mizushima; R van der Zee; M R Stanford; J Sanderson; T Lehner Journal: Lancet Date: 1996-03-23 Impact factor: 79.321
Authors: M Satoh; S Seki; W Hashimoto; K Ogasawara; T Kobayashi; K Kumagai; S Matsuno; K Takeda Journal: J Immunol Date: 1996-11-01 Impact factor: 5.422
Authors: S B Wilson; S C Kent; K T Patton; T Orban; R A Jackson; M Exley; S Porcelli; D A Schatz; M A Atkinson; S P Balk; J L Strominger; D A Hafler Journal: Nature Date: 1998-01-08 Impact factor: 49.962
Authors: T Sumida; A Sakamoto; H Murata; Y Makino; H Takahashi; S Yoshida; K Nishioka; I Iwamoto; M Taniguchi Journal: J Exp Med Date: 1995-10-01 Impact factor: 14.307