Literature DB >> 10574661

Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro.

L Bretillon1, J M Chardigny, S Grégoire, O Berdeaux, J L Sébédio.   

Abstract

The influence of individual conjugated linoleic acid (CLA) isomers on the delta6 desaturation of linoleic and alpha-linolenic acids and on the delta9 desaturation of stearic acid was investigated in vitro, using rat liver microsomes. The delta6 desaturation of 18:2n-6 was decreased from 23 to 38% when the ratio of 9cis,11trans-18:2 to 18:2n-6 increased from 0.5 to 2. The compound 10trans,12cis-18:2 exhibited a similar effect only at the highest concentration. The delta6 desaturation of alpha-linolenic acid was slightly affected by the presence of CLA isomers. The sole isomer to induce an inhibitory effect on the delta9 desaturation of stearic acid was 10trans,12cis-18:2.

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Year:  1999        PMID： 10574661     DOI： 10.1007/s11745-999-0446-9

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  25 in total

1.  Conversion of 18:3 delta 9cis, 12cis, 15trans in rat liver microsomes.

Authors:  J M Chardigny; J P Blond; L Bretillon; E Mager; D Poullain; L Martine; J M Vatèle; J P Noĕl; J L Sébédio
Journal:  Lipids       Date:  1997-07       Impact factor: 1.880

2.  Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters.

Authors:  R J Nicolosi; E J Rogers; D Kritchevsky; J A Scimeca; P J Huth
Journal:  Artery       Date:  1997

3.  Conjugated linoleic acids alter bone fatty acid composition and reduce ex vivo prostaglandin E2 biosynthesis in rats fed n-6 or n-3 fatty acids.

Authors:  Y Li; B A Watkins
Journal:  Lipids       Date:  1998-04       Impact factor: 1.880

4.  Silver-ion high-performance liquid chromatographic separation and identification of conjugated linoleic acid isomers.

Authors:  N Sehat; M P Yurawecz; J A Roach; M M Mossoba; J K Kramer; Y Ku
Journal:  Lipids       Date:  1998-02       Impact factor: 1.880

5.  Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse.

Authors:  D B West; J P Delany; P M Camet; F Blohm; A A Truett; J Scimeca
Journal:  Am J Physiol       Date:  1998-09

6.  Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression.

Authors:  K N Lee; M W Pariza; J M Ntambi
Journal:  Biochem Biophys Res Commun       Date:  1998-07-30       Impact factor: 3.575

7.  Mammary cancer prevention by conjugated dienoic derivative of linoleic acid.

Authors:  C Ip; S F Chin; J A Scimeca; M W Pariza
Journal:  Cancer Res       Date:  1991-11-15       Impact factor: 12.701

8.  PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL.

Authors:  W R MORRISON; L M SMITH
Journal:  J Lipid Res       Date:  1964-10       Impact factor: 5.922

9.  Maintenance of lower proportions of (n - 6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n - 3) fatty acids.

Authors:  W E Lands; B Libelt; A Morris; N C Kramer; T E Prewitt; P Bowen; D Schmeisser; M H Davidson; J H Burns
Journal:  Biochim Biophys Acta       Date:  1992-12-10

10.  The role of delta-6- and delta-9-desaturase in the fatty acid metabolism of hepatomas with different growth rate.

Authors:  S Hrelia; A Bordoni; P L Biagi; T Galeotti; G Palombini; L Masotti
Journal:  Biochem Mol Biol Int       Date:  1994-10
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  24 in total

1.  Effect of conjugated linoleic acid on fungal delta6-desaturase activity in a transformed yeast system.

Authors:  L T Chuang; J M Thurmond; J W Liu; S J Kirchner; P Mukerji; T M Bray; Y S Huang
Journal:  Lipids       Date:  2001-02       Impact factor: 1.880

2.  Beta-oxidation of conjugated linoleic acid isomers and linoleic acid in rats.

Authors:  J P Sergiel; J M Chardigny; J L Sébédio; O Berdeaux; P Juaneda; O Loreau; B Pasquis; J P Noel
Journal:  Lipids       Date:  2001-12       Impact factor: 1.880

3.  Comparison of silver-ion high-performance liquid chromatographic quantification of free and methylated conjugated linoleic acids.

Authors:  E Ostrowska; F R Dunshea; M Muralitharan; R F Cross
Journal:  Lipids       Date:  2000-10       Impact factor: 1.880

4.  Vaccenic acid metabolism in the liver of rat and bovine.

Authors:  Dominique Gruffat; Anne De La Torre; Jean-Michel Chardigny; Denys Durand; Olivier Loreau; Dominique Bauchart
Journal:  Lipids       Date:  2005-03       Impact factor: 1.880

5.  In vitro comparison of hepatic metabolism of 9cis-11 trans and 10trans-12cis isomers of CLA in the rat.

Authors:  Dominique Gruffat; Anne De La Torre; Jean-Michel Chardigny; Denys Durand; Olivier Loreau; Jean-Louis Sébédio; Dominique Bauchart
Journal:  Lipids       Date:  2003-02       Impact factor: 1.880

6.  Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes.

Authors:  J Mark Brown; Maria Sandberg Boysen; Søren Skov Jensen; Ron F Morrison; Jayne Storkson; Renee Lea-Currie; Michael Pariza; Susanne Mandrup; Michael K McIntosh
Journal:  J Lipid Res       Date:  2003-05-01       Impact factor: 5.922

7.  Effect of CLA on milk fat synthesis in dairy cows: comparison of inhibition by methyl esters and free fatty acids, and relationships among studies.

Authors:  Michael J de Veth; J Mikko Griinari; Angelika-Maria Pfeiffer; Dale E Bauman
Journal:  Lipids       Date:  2004-04       Impact factor: 1.880

8.  Influence of dietary conjugated linoleic acid on growth, fatty acid composition and hepatic lipogenesis in large yellow croaker (Pseudosciaena crocea R.).

Authors:  Zhan-yu Zhao; Tian-xing Wu; Hong-gang Tang; Ji-ze Zhang
Journal:  J Zhejiang Univ Sci B       Date:  2008-09       Impact factor: 3.066

9.  Dietary CLA and DHA modify skin properties in mice.

Authors:  Daichi Oikawa; Tomonori Nakanishi; Yoshinori Nakamura; Yukiko Takahashi; Takaya Yamamoto; Nobuya Shiba; Manabu Tobisa; Tomo Takagi; Hisao Iwamoto; Tetsuya Tachibana; Mitsuhiro Furuse
Journal:  Lipids       Date:  2003-06       Impact factor: 1.880

10.  Dietary conjugated linoleic acid renal benefits and possible toxicity vary with isomer, dose and gender in rat polycystic kidney disease.

Authors:  Malcolm R Ogborn; Evan Nitschmann; Aviva Goldberg; Neda Bankovic-Calic; Hope A Weiler; Harold M Aukema
Journal:  Lipids       Date:  2008-07-16       Impact factor: 1.880
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