Literature DB >> 10574507

Peroxisome proliferator-activated receptor-gamma: a versatile metabolic regulator.

S Rocchi1, J Auwerx.   

Abstract

The peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear receptor that controls the expression of a large array of genes involved in adipocyte differentiation, lipid storage and insulin sensitization. PPARgamma is bound and activated by prostaglandin J2 and fatty acid derivatives, which are its natural ligands. In addition, thiazolidinediones and nonsteroidal anti-inflammatory drugs are synthetic ligands and agonists of this receptor. Several studies have recently shown that this nuclear receptor has a role expanding beyond metabolism (diabetes and obesity) with functions in cell cycle control, carcinogenesis, inflammation and atherosclerosis. This review addresses the role of PPARgamma in these processes.

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Year:  1999        PMID： 10574507     DOI： 10.3109/07853899908995901

Source DB:  PubMed          Journal:  Ann Med        ISSN： 0785-3890            Impact factor:   4.709


  15 in total

1.  The increased gastroprotective effect of pioglitazone in cholestatic rats: role of nitric oxide and tumour necrosis factor alpha.

Authors:  Leila Moezi; Zeinab Janahmadi; Zahra Amirghofran; Ali Akbar Nekooeian; Ahmad R Dehpour
Journal:  Int J Exp Pathol       Date:  2014-02       Impact factor: 1.925

2.  In vivo and in vitro evidence that PPARγ ligands are antagonists of leptin signaling in breast cancer.

Authors:  Stefania Catalano; Loredana Mauro; Daniela Bonofiglio; Michele Pellegrino; Hongyan Qi; Pietro Rizza; Donatella Vizza; Gianluca Bossi; Sebastiano Andò
Journal:  Am J Pathol       Date:  2011-06-23       Impact factor: 4.307

3.  Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver.

Authors:  Romi Ghose; Jaap Mulder; Richard J von Furstenberg; Sundararajah Thevananther; Folkert Kuipers; Saul J Karpen
Journal:  J Hepatol       Date:  2006-10-23       Impact factor: 25.083

Review 4.  Diet, fatty acids, and regulation of genes important for heart disease.

Authors:  John P Vanden Heuvel
Journal:  Curr Atheroscler Rep       Date:  2004-11       Impact factor: 5.113

5.  Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock.

Authors:  Ranjit S Chima; Paul W Hake; Giovanna Piraino; Prajakta Mangeshkar; Alvin Denenberg; Basilia Zingarelli
Journal:  Crit Care Med       Date:  2008-10       Impact factor: 7.598

6.  Meal intake similarly reduces circulating concentrations of octanoyl and total ghrelin in humans.

Authors:  P Lucidi; G Murdolo; C Di Loreto; N Parlanti; A De Cicco; A Ranchelli; C Fatone; C Taglioni; C Fanelli; F Santeusanio; P De Feo
Journal:  J Endocrinol Invest       Date:  2004-05       Impact factor: 4.256

7.  Peroxisome proliferator activated receptor gamma is not necessary for the development of LPS-induced tolerance in macrophages.

Authors:  Basilia Zingarelli; Hongkuan Fan; Sarah Ashton; Giovanna Piraino; Prajakta Mangeshkar; James A Cook
Journal:  Immunology       Date:  2007-11-17       Impact factor: 7.397

8.  Genetic analysis of four novel peroxisome proliferator activated receptor-gamma splice variants in monkey macrophages.

Authors:  Jiming Zhou; Katina M Wilson; Jheem D Medh
Journal:  Biochem Biophys Res Commun       Date:  2002-04-26       Impact factor: 3.575

Review 9.  Cardiovascular disease-related genes and regulation by diet.

Authors:  John P Vanden Heuvel
Journal:  Curr Atheroscler Rep       Date:  2009-11       Impact factor: 5.113

10.  A PPARγ ligand present in Actinidia fruit (Actinidia chrysantha) is identified as dilinolenoyl galactosyl glycerol.

Authors:  Harry Martin; Tony K McGhie; Rona C M Lunken
Journal:  Biosci Rep       Date:  2013-05-15       Impact factor: 3.840
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