Literature DB >> 10574260

Activation of cyclin D1-related kinase in human lung adenocarcinoma.

K Igarashi1, T Masaki, Y Shiratori, W Rengifo, T Nagata, K Hara, T Oka, J Nakajima, T Hisada, E Hata, M Omata.   

Abstract

Cyclin D1 gene amplification is an important event in many cancers, but it is rarely found in non-small-cell lung cancer (NSCLC). This study was conducted in an attempt to clarify any other mechanisms related to cyclin D1 involvement in the malignant transformation of NSCLC, and we clearly showed for the first time that cyclin D1-related kinases are activated in NSCLC, especially in adenocarcinoma but not in squamous cell carcinoma. The results of this study strongly suggest that enhanced cyclin D1-related kinase activity could contribute to a progression of adenocarcinoma in NSCLC.

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Year:  1999        PMID： 10574260      PMCID： PMC2362904          DOI： 10.1038/sj.bjc.6690752

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  20 in total

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  5 in total

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