| Literature DB >> 10574227 |
G Clementi1, A Caruso, V M Cutuli, A Prato, N G Mangano, M Amico-Roxas.
Abstract
The antiinflammatory effect of ADM was studied in different models of inflammation and compared to the one of CGRP. Peptides were active against acetic acid-induced peritonitis in the rats. ADM and CGRP exerted the antiinflammatory effect at different doses, 400 and 20 ng/kg respectively, but with different efficacy (ADM >CGRP). This effect was blocked by pretreatment with CGRP (8-37) fragment or with L-NAME. No antiinflammatory activity was evidenced against serotonin- or carrageenin-induced rat paw edema. Our data suggest that ADM exerts antiinflammatory activity in the model characterized by a vascular component. This effect involves CGRP receptors and appears to be mediated by nitric oxide system.Entities:
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Year: 1999 PMID： 10574227 DOI： 10.1016/s0024-3205(99)00406-3
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037