Literature DB >> 10574204

Determination of urinary orotic acid and uracil by capillary zone electrophoresis.

C Salerno1, P D'Eufemia, M Celli, R Finocchiaro, C Crifò, O Giardini.   

Abstract

We describe a simple method for measuring orotic acid and uracil concentration in urine by capillary zone electrophoresis in 20 mM Na-borate buffer, pH 9.2. The method was applied for studying a patient with HHH (hyperomithinemia, hyperammonemia and homocitrullinuria) syndrome. A high value of uracil excretion was found during periods of relatively low orotic acid excretion and normal ammonemia. The orotic acid level in urine was increased by increasing protein intake.

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Year:  1999        PMID： 10574204     DOI： 10.1016/s0378-4347(99)00337-0

Source DB:  PubMed          Journal:  J Chromatogr B Biomed Sci Appl        ISSN： 1387-2273


  1 in total

1.  Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures.

Authors:  Joo Sang Lee; Lital Adler; Hiren Karathia; Narin Carmel; Shiran Rabinovich; Noam Auslander; Rom Keshet; Noa Stettner; Alon Silberman; Lilach Agemy; Daniel Helbling; Raya Eilam; Qin Sun; Alexander Brandis; Sergey Malitsky; Maxim Itkin; Hila Weiss; Sivan Pinto; Shelly Kalaora; Ronen Levy; Eilon Barnea; Arie Admon; David Dimmock; Noam Stern-Ginossar; Avigdor Scherz; Sandesh C S Nagamani; Miguel Unda; David M Wilson; Ronit Elhasid; Arkaitz Carracedo; Yardena Samuels; Sridhar Hannenhalli; Eytan Ruppin; Ayelet Erez
Journal:  Cell       Date:  2018-08-09       Impact factor: 41.582
  1 in total

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