OBJECTIVE: To determine whether the calcium-dependent cell adhesion molecule E-cadherin is expressed in metastatic deposits of prostate cancer in bone. PATIENTS AND METHODS: Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were obtained and immunohistochemically stained for E-cadherin with the monoclonal antibody HECD-1, using the streptavidin-biotin complex technique. Benign prostatic tissue was used as the control. RESULTS: Of the 10 specimens, nine showed positive expression of E-cadherin, graded as strong in four. E-cadherin expression was strongest in well-differentiated metastases and decreased with increasing tumour grade. In some specimens there were mixed patterns of expression. CONCLUSION: E-cadherin is strongly expressed in prostatic bone metastases and the degree of expression appears to reflect local tumour grade. This suggests that loss of E-cadherin expression may not be critically linked to metastatic potential.
OBJECTIVE: To determine whether the calcium-dependent cell adhesion molecule E-cadherin is expressed in metastatic deposits of prostate cancer in bone. PATIENTS AND METHODS: Ten bone biopsies containing metastatic deposits of untreated prostatic cancer were obtained and immunohistochemically stained for E-cadherin with the monoclonal antibody HECD-1, using the streptavidin-biotin complex technique. Benign prostatic tissue was used as the control. RESULTS: Of the 10 specimens, nine showed positive expression of E-cadherin, graded as strong in four. E-cadherin expression was strongest in well-differentiated metastases and decreased with increasing tumour grade. In some specimens there were mixed patterns of expression. CONCLUSION:E-cadherin is strongly expressed in prostatic bone metastases and the degree of expression appears to reflect local tumour grade. This suggests that loss of E-cadherin expression may not be critically linked to metastatic potential.
Authors: Jeroen T Buijs; Niek V Henriquez; Petra G M van Overveld; Geertje van der Horst; Peter ten Dijke; Gabri van der Pluijm Journal: Clin Exp Metastasis Date: 2007-11-16 Impact factor: 5.150
Authors: Jeroen T Buijs; Cyrill A Rentsch; Geertje van der Horst; Petra G M van Overveld; Antoinette Wetterwald; Ruth Schwaninger; Niek V Henriquez; Peter Ten Dijke; Fran Borovecki; Regula Markwalder; George N Thalmann; Socrates E Papapoulos; Rob C M Pelger; Slobodan Vukicevic; Marco G Cecchini; Clemens W G M Löwik; Gabri van der Pluijm Journal: Am J Pathol Date: 2007-09 Impact factor: 4.307
Authors: Won Jin Cho; Daniel S M Oliveira; Abdo J Najy; Leandro E Mainetti; Hussein D Aoun; Michael L Cher; Elisabeth Heath; Hyeong-Reh C Kim; R Daniel Bonfil Journal: J Transl Med Date: 2016-03-15 Impact factor: 5.531