| Literature DB >> 10571239 |
W K Kim1, Y B Choi, P V Rayudu, P Das, W Asaad, D R Arnelle, J S Stamler, S A Lipton.
Abstract
Recent evidence indicates that the NO-related species, nitroxyl anion (NO), is produced in physiological systems by several redox metal-containing proteins, including hemoglobin, nitric oxide synthase (NOS), superoxide dismutase, and S-nitrosothiols (SNOs), which have recently been identified in brain. However, the chemical biology of NO- remains largely unknown. Here, we show that NO- -unlike NO*, but reminiscent of NO+ transfer (or S-nitrosylation)- -reacts mainly with Cys-399 in the NR2A subunit of the N-methyl-D-aspartate (NMDA) receptor to curtail excessive Ca2+ influx and thus provide neuroprotection from excitotoxic insults. This effect of NO- closely resembles that of NOS, which also downregulates NMDA receptor activity under similar conditions in culture.Entities:
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Year: 1999 PMID： 10571239 DOI： 10.1016/s0896-6273(00)80859-4
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173