Literature DB >> 10571175

Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives.

M Ohyama1, T Tanaka, T Ito, M Iinuma, K F Bastow, K H Lee.   

Abstract

Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The acetate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activity with ED50 values of 0.6, 0.7 and 2.0 microg/mL against KB, 1A9 and MCF-7 cells, respectively. Hopeaphenol (10) and pallidol hexaacetate (13) also showed significant cytotoxicity against KB cells with ED50 values of 1.2 and 1.6 microg/mL, respectively.

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Year:  1999        PMID： 10571175     DOI： 10.1016/s0960-894x(99)00520-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

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Review 2.  Chemistry and Biology of Resveratrol-Derived Natural Products.

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Review 4.  Applications of Friedel-Crafts reactions in total synthesis of natural products.

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Review 5.  Resveratrol oligomers for the prevention and treatment of cancers.

Authors:  You-Qiu Xue; Jin-Ming Di; Yun Luo; Ke-Jun Cheng; Xing Wei; Zhi Shi
Journal:  Oxid Med Cell Longev       Date:  2014-03-23       Impact factor: 6.543

6.  Pharmacokinetics, bioavailability, metabolism and excretion of δ-viniferin in rats.

Authors:  Ping Mao; Yinping Lei; Tingting Zhang; Chen Ma; Bo Jin; Tong Li
Journal:  Acta Pharm Sin B       Date:  2016-04-21       Impact factor: 11.413

7.  Pharmacokinetic analysis and tissue distribution of Vam3 in the rat by a validated LC-MS/MS method.

Authors:  Ruixia Zhang; Ping Mao; Tingting Zhang; Chen Ma; Bo Jin; Tong Li
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  7 in total

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