| Literature DB >> 10571162 |
A Asai1, S Nagamura, E Kobayashi, K Gomi, H Saito.
Abstract
The water-soluble duocarmycin B1 prodrugs such as glycoside 3, phosphate 4 and carbamate 5 were synthesized for improving biological and pharmaceutical profiles of duocarmycin. Among these prodrugs, N-methylpiperazinylcarbamoyl derivative 5 exhibited potent antitumor activity against several human tumors in vivo.Entities:
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Year: 1999 PMID： 10571162 DOI： 10.1016/s0960-894x(99)00518-1
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823