| Literature DB >> 10571153 |
R M Kanojia1, W Murray, J Bernstein, J Fernandez, B D Foleno, H Krause, L Lawrence, G Webb, J F Barrett.
Abstract
A series of 6-oxa isosteres of anacardic acids (6-higher alkyl/alkenyl-2-hydroxybenzoic acids) was synthesised and several members were discovered to be among the most potent inhibitors (IC50 values < or = 5 microM) of the bacterial two-component regulatory systems, KinA/SpoOF and NRII/NRI, reported to date. The Gram-positive antibacterial activity in selected strains is also presented.Entities:
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Year: 1999 PMID： 10571153 DOI： 10.1016/s0960-894x(99)00508-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823