Literature DB >> 10570949

Strain- and age-dependent loss of sarcoglycan complex in cardiomyopathic hamster hearts and its re-expression by delta-sarcoglycan gene transfer in vivo.

T Kawada1, Y Nakatsuru, A Sakamoto, T Koizumi, W S Shin, Y Okai-Matsuo, J Suzuki, Y Uehara, M Nakazawa, H Sato, T Ishikawa, T Toyo-oka.   

Abstract

The delta-sarcoglycan (SG) gene is deleted in hamsters with hereditary cardiomyopathies. Immunological analyses of heart before, but not after, the progression of cardiomyopathy (CM) revealed that the BIO 14.6 strain, a model of hypertrophic CM, heterogeneously preserved alpha- and gamma-SG with loss of beta- and delta-SG. In contrast, the TO-2 strain, a model of dilated CM, did not show either SG. Furthermore, in vivo transfer of the full length delta-SG gene to TO-2 hearts expressed all four SGs. Thus, this age- and strain-dependent features suggest a more feasible setting for TO-2 than BIO 14.6 to verify both CM progression and the efficacy of gene therapy.

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Year:  1999        PMID： 10570949     DOI： 10.1016/s0014-5793(99)01164-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Rescue of hereditary form of dilated cardiomyopathy by rAAV-mediated somatic gene therapy: amelioration of morphological findings, sarcolemmal permeability, cardiac performances, and the prognosis of TO-2 hamsters.

Authors:  Tomie Kawada; Mikio Nakazawa; Sakura Nakauchi; Ken Yamazaki; Ryoichi Shimamoto; Masashi Urabe; Jumi Nakata; Chieko Hemmi; Fujiko Masui; Toshiaki Nakajima; Jun-Ichi Suzuki; John Monahan; Hiroshi Sato; Tomoh Masaki; Keiya Ozawa; Teruhiko Toyo-Oka
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-22       Impact factor: 11.205

2.  Hemodynamic alterations in the coronary circulation of cardiomyopathic hamsters: age and Ang II-dependent mechanisms.

Authors:  Nelson Escobales; Jose A Ramos; Guido E Santacana; Maria J Crespo
Journal:  J Card Fail       Date:  2009-08-20       Impact factor: 5.712

3.  Kappa and delta opioid receptor signaling is augmented in the failing heart.

Authors:  Craig Bolte; Gilbert Newman; Jo El J Schultz
Journal:  J Mol Cell Cardiol       Date:  2009-06-30       Impact factor: 5.000

4.  Specific knockdown of delta-sarcoglycan gene in C2C12 in vitro causes post-translational loss of other sarcoglycans without mechanical stress.

Authors:  Michiyo Honda; Mari Hosoda; Nobuyuki Kanzawa; Takahide Tsuchiya; Teruhiko Toyo-oka
Journal:  Mol Cell Biochem       Date:  2008-12-16       Impact factor: 3.396

5.  Sarcolemmal fragility secondary to the degradation of dystrophin in dilated cardiomyopathy, as estimated by electron microscopy.

Authors:  Tomie Kawada; Chieko Hemmi; Satoru Fukuda; Asaki Tezuka; Kuniaki Iwasawa; Mikio Nakazawa; Hiroshi Sato; Teruhiko Toyo-Oka
Journal:  Exp Clin Cardiol       Date:  2003

6.  Translocation and cleavage of myocardial dystrophin as a common pathway to advanced heart failure: a scheme for the progression of cardiac dysfunction.

Authors:  Teruhiko Toyo-Oka; Tomie Kawada; Jumi Nakata; Han Xie; Masashi Urabe; Fujiko Masui; Takashi Ebisawa; Asaki Tezuka; Kuniaki Iwasawa; Toshiaki Nakajima; Yoshio Uehara; Hiroyuki Kumagai; Sawa Kostin; Jutta Schaper; Mikio Nakazawa; Keiya Ozawa
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-05       Impact factor: 11.205

7.  SERCA2a gene therapy can improve symptomatic heart failure in δ-sarcoglycan-deficient animals.

Authors:  Sophie Bouyon; Véronique Roussel; Yves Fromes
Journal:  Hum Gene Ther       Date:  2014-08       Impact factor: 5.695

8.  δ-Sarcoglycan-deficient muscular dystrophy: from discovery to therapeutic approaches.

Authors:  Alison M Blain; Volker W Straub
Journal:  Skelet Muscle       Date:  2011-03-17       Impact factor: 4.912
  8 in total

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