| Literature DB >> 10568521 |
P Cuevas1, D Reimers, D Diaz, R M Lozano, G Giménez-Gallego.
Abstract
Fibroblast growth factors (FGFs) are powerful angiogenic polypeptides that are involved in the autocrine growth stimulation of gliomas. We report here that addition to glioma cell cultures of 1,3,6-naphthalenetrisulfonate (NTS), an inhibitor of the mitogenic activity of FGFs, significantly enhanced apoptosis, as assessed by terminal deoxynucleotidyl transferase (TdT) assay. The pro-apoptotic effect of NTS was time-dependent. These findings suggest that FGF may play a pivotal role in the survival of glioma cells, and support a clinical interest of NTS as a leading compound for the development of new antitumorals.Entities:
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Year: 1999 PMID： 10568521 DOI： 10.1016/s0304-3940(99)00752-1
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046