| Literature DB >> 10568208 |
T Arakawa1, K Higuchi, Y Fujiwara, T Watanabe, K Tominaga, T Hayakawa, T Kuroki.
Abstract
Liu-Jun-Zi-Tang (TJ-43), a herbal medicine exerting gastroprotective action, was examined for its mechanism of action in rats. TJ-43 significantly inhibited gastric mucosal damage caused by absolute ethanol at doses over 500 mg/kg in a dose-dependent way. Pretreatment with indomethacin or with N-ethylmaleimide did not affect the gastroprotective effect of TJ-43. However, pretreatment with NG-nitro-L-arginine partially but significantly reversed the protective effect of this drug. These findings suggest that the gastroprotective effect of TJ-43 occurs partly through nitric oxide but not through prostaglandins or sulfhydryls.Entities:
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Year: 1999 PMID： 10568208
Source DB: PubMed Journal: Drugs Exp Clin Res ISSN： 0378-6501