The impact of L-arginine-nitric oxide metabolism on ischemia/reperfusion injury.

Several experimental studies have revealed that the administration of L-arginine can reduce ischemia/reperfusion injury to skeletal muscle, kidney, liver, heart and brain. Moreover, the administration of L-arginine can cause protective hemodynamic alterations. However, in situations with a stimulated inducible NOS, the administration of large amounts of L-arginine may be hazardous for the patients.