Literature DB >> 10565304

Chronic myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98/HOXA9 fusion.

K F Wong1, C C So, Y L Kwong.   

Abstract

Translocation (7;11)(p15;p15) is a recently characterized chromosomal abnormality that results in fusion of the NUP98 gene on 11p15 and the HOXA9 gene on 7p15. It shows a strong racial predisposition, being found predominantly in Oriental patients, and has been reported almost exclusively in acute myeloid leukemia, often with associated myelodysplastic changes. In this report, we describe the unique occurrence of t(7;11)(p15;p15) and NUP98/HOXA9 fusion in a patient with chronic myelomonocytic leukemia, and suggest that the genetic lesion may involve multipotential myeloid stem cells.

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Year:  1999        PMID： 10565304     DOI： 10.1016/s0165-4608(99)00085-0

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  6 in total

1.  Atypical chronic myeloid leukemia harboring NUP98-HOXA9.

Authors:  Hiromichi Murayama; Hiromichi Matsushita; Kiyoshi Ando
Journal:  Int J Hematol       Date:  2013-06-11       Impact factor: 2.490

2.  NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice.

Authors:  E Kroon; U Thorsteinsdottir; N Mayotte; T Nakamura; G Sauvageau
Journal:  EMBO J       Date:  2001-02-01       Impact factor: 11.598

3.  A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9.

Authors:  Ajeeta B Dash; Ifor R Williams; Jeffery L Kutok; Michael H Tomasson; Ema Anastasiadou; Kathleen Lindahl; Shaoguang Li; Richard A Van Etten; Julian Borrow; David Housman; Brian Druker; D Gary Gilliland
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

4.  Differential requirements for myeloid leukemia IFN-γ conditioning determine graft-versus-leukemia resistance and sensitivity.

Authors:  Catherine Matte-Martone; Jinling Liu; Meng Zhou; Maria Chikina; Douglas R Green; John T Harty; Warren D Shlomchik
Journal:  J Clin Invest       Date:  2017-06-12       Impact factor: 14.808

5.  A case of acute myeloid leukemia with t(7;11)(p15;p15) mimicking myeloid crisis of chronic myelogenous leukemia.

Authors:  Keiki Kawakami; Setsuko Miyanishi; Kazuhiho Nishii; Eiji Usui; Tetsuya Murata; Isaku Shinsato; Hiroshi Shiku
Journal:  Int J Hematol       Date:  2002-07       Impact factor: 2.490

6.  Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EmuMyc lymphomagenesis: a tumor suppressor role for Prep1.

Authors:  E Longobardi; G Iotti; P Di Rosa; S Mejetta; F Bianchi; L C Fernandez-Diaz; N Micali; P Nuciforo; E Lenti; M Ponzoni; C Doglioni; M Caniatti; P P Di Fiore; F Blasi
Journal:  Mol Oncol       Date:  2010-01-07       Impact factor: 6.603
  6 in total

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