Literature DB >> 10562290

The role of presenilins in Alzheimer's disease.

G Thinakaran1.   

Abstract

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10562290      PMCID： PMC409849          DOI： 10.1172/JCI8728

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


× No keyword cloud information.
  33 in total

1.  Proteolysis by presenilins and the renaissance of tau.

Authors:  C Haass; E Mandelkow
Journal:  Trends Cell Biol       Date:  1999-06       Impact factor: 20.808

2.  gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length.

Authors:  M P Murphy; L J Hickman; C B Eckman; S N Uljon; R Wang; T E Golde
Journal:  J Biol Chem       Date:  1999-04-23       Impact factor: 5.157

3.  Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Authors:  M S Wolfe; W Xia; B L Ostaszewski; T S Diehl; W T Kimberly; D J Selkoe
Journal:  Nature       Date:  1999-04-08       Impact factor: 49.962

4.  Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

Authors:  Y Ye; N Lukinova; M E Fortini
Journal:  Nature       Date:  1999-04-08       Impact factor: 49.962

5.  Presenilin is required for activity and nuclear access of Notch in Drosophila.

Authors:  G Struhl; I Greenwald
Journal:  Nature       Date:  1999-04-08       Impact factor: 49.962

6.  A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

Authors:  B De Strooper; W Annaert; P Cupers; P Saftig; K Craessaerts; J S Mumm; E H Schroeter; V Schrijvers; M S Wolfe; W J Ray; A Goate; R Kopan
Journal:  Nature       Date:  1999-04-08       Impact factor: 49.962

7.  Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes.

Authors:  T P Wong; T Debeir; K Duff; A C Cuello
Journal:  J Neurosci       Date:  1999-04-01       Impact factor: 6.167

8.  Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.

Authors:  D E Kang; S Soriano; M P Frosch; T Collins; S Naruse; S S Sisodia; G Leibowitz; F Levine; E H Koo
Journal:  J Neurosci       Date:  1999-06-01       Impact factor: 6.167

9.  Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.

Authors:  A Parent; D J Linden; S S Sisodia; D R Borchelt
Journal:  Neurobiol Dis       Date:  1999-02       Impact factor: 5.996

10.  Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3.

Authors:  P Vito; E Lacanà; L D'Adamio
Journal:  Science       Date:  1996-01-26       Impact factor: 47.728
View more
  15 in total

1.  Presenilin 1 forms aggresomal deposits in response to heat shock.

Authors:  Imre Kovacs; Kristen M Lentini; Laura MacKenzie Ingano; Dora M Kovacs
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

2.  Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease.

Authors:  R B DeMattos; K R Bales; D J Cummins; J C Dodart; S M Paul; D M Holtzman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-03       Impact factor: 11.205

Review 3.  Genetic therapy for the nervous system.

Authors:  William J Bowers; Xandra O Breakefield; Miguel Sena-Esteves
Journal:  Hum Mol Genet       Date:  2011-03-23       Impact factor: 6.150

Review 4.  The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking.

Authors:  J T Mack; V Beljanski; K D Tew; D M Townsend
Journal:  Biomed Pharmacother       Date:  2006-08-31       Impact factor: 6.529

5.  N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease.

Authors:  Koichi Ando; Kengo Uemura; Akira Kuzuya; Masato Maesako; Megumi Asada-Utsugi; Masakazu Kubota; Nobuhisa Aoyagi; Katsuji Yoshioka; Katsuya Okawa; Haruhisa Inoue; Jun Kawamata; Shun Shimohama; Tetsuaki Arai; Ryosuke Takahashi; Ayae Kinoshita
Journal:  J Biol Chem       Date:  2010-12-22       Impact factor: 5.157

6.  Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1.

Authors:  Zhongcong Xie; Donna M Romano; Rudolph E Tanzi
Journal:  J Mol Neurosci       Date:  2005       Impact factor: 3.444

7.  Structure nor stability of the transmembrane spanning 6/7 domain of presenilin I correlates with pathogenicity.

Authors:  Brian Jeppesen; Laura Costello; Adam Fung; Erin Stanley; Jessica McDonald; Abbie Lambert; Bennett Johnson; Lisa Gentile
Journal:  Biochem Biophys Res Commun       Date:  2007-02-15       Impact factor: 3.575

Review 8.  Alzheimer's disease: the challenge of the second century.

Authors:  David M Holtzman; John C Morris; Alison M Goate
Journal:  Sci Transl Med       Date:  2011-04-06       Impact factor: 17.956

9.  X-Module: A novel fusion measure to associate co-expressed gene modules from condition-specific expression profiles.

Authors:  Tulika Kakati; Dhruba K Bhattacharyya; Jugal K Kalita
Journal:  J Biosci       Date:  2020       Impact factor: 1.826

Review 10.  Mitochondrial quality control and neurological disease: an emerging connection.

Authors:  Inês Pimenta de Castro; L Miguel Martins; Roberta Tufi
Journal:  Expert Rev Mol Med       Date:  2010-04-19       Impact factor: 5.600
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.