Literature DB >> 10561469

Cellular internalization of PCL(20)-b-PEO(44) block copolymer micelles.

C Allen1, Y Yu, A Eisenberg, D Maysinger.   

Abstract

The cellular internalization of polycaprolactone-b-poly(ethylene oxide) (PCL(20)-b-PEO(44)) copolymer micelles were investigated in PC12 cells cultures. The micelles were found to be internalized into PC12 cells when followed over the 4-h incubation period. Also, the internalization process was found to fulfill the basic criteria for endocytotic uptake in that it was time, temperature, pH and energy dependent. In addition, the use of other pharmacological manipulations (hypertonic treatment, Brefeldin A) provide further evidence that the mode of cellular internalization is in fact endocytotic.

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Year:  1999        PMID： 10561469     DOI： 10.1016/s0005-2736(99)00108-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  22 in total

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