| Literature DB >> 10560741 |
C Haubmann1, H Hübner, P Gmeiner.
Abstract
Piperidinylpyrroles of type 3 were synthesized through a modified Paal-Knorr reaction. For the introduction of pyrrole-substituents high yielding transformations including Sonogashira cross-coupling reactions were utilized. Employment of the reagent TosMIC gave access to the regioisomeric oxazolyl derivatives 7 and 11 which showed the highest dopamine D4 receptor binding of the series investigated.Entities:
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Year: 1999 PMID： 10560741 DOI： 10.1016/s0960-894x(99)00540-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823