| Literature DB >> 10560734 |
W C Shakespeare1, R S Bohacek, S S Narula, M D Azimioara, R W Yuan, D C Dalgarno, L Madden, M C Botfield, D A Holt.
Abstract
A CuBr-mediated, regioselective cross-coupling between methyl 2,5-diiodobenzoate (4) and [(diethoxyphosphinyl)difluoromethyl]zinc bromide is reported. Palladium-catalyzed incorporation of an amino acid side chain, followed by subsequent modifications resulted in the rapid construction of 2. Compound 2 was designed to engage Cys188 of the Src SH2 domain, however, this was not observed spectroscopically.Entities:
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Year: 1999 PMID： 10560734 DOI： 10.1016/s0960-894x(99)00545-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823