Literature DB >> 10560366

Histopathological study of the human submandibular gland in graft versus host disease.

R M Nagler1, Y Sherman, A Nagler.   

Abstract

Major salivary gland dysfunction and severe xerostomia is one of the manifestations of graft versus host disease (GVHD). The histopathological evaluation of the major salivary gland in patients with GVHD has never been reported. The pathological findings of the submandibular glands in a GVHD patient who succumbed to the disease are described. Lymphocytic infiltration, parenchymal destruction, and fibrosis were observed, which may provide the pathophysiological mechanism for the xerostomia and hyposalivation observed in GVHD.

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Mesh：

Year:  1999        PMID： 10560366      PMCID： PMC1023082          DOI： 10.1136/jcp.52.5.395

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  33 in total

1.  Radiation-induced xerostomia in cancer patients. Effect on salivary and serum electrolytes.

Authors:  S Dreizen; L R Brown; S Handler; B M Levy
Journal:  Cancer       Date:  1976-07       Impact factor: 6.860

2.  Short- and long-term functional vs morphometrical salivary effects of irradiation in a rodent model.

Authors:  R M Nagler
Journal:  Anticancer Res       Date:  1998 Jan-Feb       Impact factor: 2.480

3.  Parotid gland dysfunction in a murine model of acute graft versus host disease [aGVHD].

Authors:  R M Nagler; D Laufer; A Nagler
Journal:  Head Neck       Date:  1998-01       Impact factor: 3.147

4.  Effect of radiotherapy on whole saliva flow.

Authors:  I L Shannon; E N Starcke; W B Wescott
Journal:  J Dent Res       Date:  1977-06       Impact factor: 6.116

5.  Prevention of xerostomia-related dental caries in irradiated cancer patients.

Authors:  S Dreizen; L R Brown; T E Daly; J B Drane
Journal:  J Dent Res       Date:  1977-02       Impact factor: 6.116

6.  Sjögren-type syndrome after allogeneic bone-marrow transplantation.

Authors:  A A Gratwohl; A A Gratwhol; H M Moutsopoulos; T M Chused; M Akizuki; R O Wolf; J B Sweet; A B Deisseroth
Journal:  Ann Intern Med       Date:  1977-12       Impact factor: 25.391

7.  X-ray-induced changes in function and structure of the rat parotid gland.

Authors:  R M Phillips
Journal:  J Oral Surg       Date:  1970-06

8.  Irradiation-induced damage to the salivary glands: the role of redox-active iron and copper.

Authors:  R Nagler; Y Marmary; P C Fox; B J Baum; R Har-El; M Chevion
Journal:  Radiat Res       Date:  1997-04       Impact factor: 2.841

9.  Parotid gland dysfunction in an animal model of chronic graft-vs-host disease.

Authors:  R M Nagler; D Laufer; A Nagler
Journal:  Arch Otolaryngol Head Neck Surg       Date:  1996-10

10.  The effect of radiation-induced xerostomia on saliva and serum lysozyme and immunoglobulin levels.

Authors:  L R Brown; S Dreizen; L J Rider; D A Johnston
Journal:  Oral Surg Oral Med Oral Pathol       Date:  1976-01
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  1 in total

Review 1.  Sex differences in Sjögren's syndrome: a comprehensive review of immune mechanisms.

Authors:  Jessica E Brandt; Roberta Priori; Guido Valesini; DeLisa Fairweather
Journal:  Biol Sex Differ       Date:  2015-11-03       Impact factor: 5.027
  1 in total

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