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Literature DB >> 1056012

Mechanism and modification of bradykinin-induced coronary vasodilation.

P Needleman, S L Key, S E Denny, P C Isakson, G R Marshall.

Abstract

In isolated perfused rabbit hearts, bradykinin produced a concentration-dependent decrease in coronary resistance directly associated with biosynthesis and release of prostaglandin-E-like substance. An inhibitor of bradykinin destruction (the nonapeptide SQ-20881) markedly enhanced both the coronary vasodilation and release of prostaglandin-E-like substance produced by cardiac injection of bradykinin. Indomethacin inhibited both the myocardial prostaglandin biosynthesis and the decrease in coronary resistance induced by bradykinin. The demonstration that bradykinin is a potent stimulator of prostaglandin biosynthesis in the heart has implications as to the cause of the afferent cardiovascular reflexes and pain in myocardial infarction and angina pectoris.

Entities: Chemical Disease Species

Mesh：

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Year: 1975 PMID： 1056012 PMCID： PMC432693 DOI： 10.1073/pnas.72.6.2060

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

26 in total

1. THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD.

Authors: J R VANE
Journal: Br J Pharmacol Chemother Date: 1964-10

2. Coronary vasodilation produced by bradykinin on isolated mammalian heart.

Authors: A ANTONIO; M ROCHA E SILVA
Journal: Circ Res Date: 1962-12 Impact factor: 17.367

3. Bradykinin.

Authors: G E BURCH; N P DEPASQUALE
Journal: Am Heart J Date: 1963-01 Impact factor: 4.749

4. A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA.

Authors: S H FERREIRA
Journal: Br J Pharmacol Chemother Date: 1965-02

5. Effects of bradykinin on the systemic and coronary vascular bed of the intact dog.

Authors: G M MAXWELL; R B ELLIOTT; G M KNEEBONE
Journal: Circ Res Date: 1962-03 Impact factor: 17.367

6. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

Authors: P J Piper; J R Vane
Journal: Nature Date: 1969-07-05 Impact factor: 49.962

Review 7. The release and fate of vaso-active hormones in the circulation.

Authors: J R Vane
Journal: Br J Pharmacol Date: 1969-02 Impact factor: 8.739

8. The release of prostaglandins from lung and other tissues.

Authors: P Piper; J Vane
Journal: Ann N Y Acad Sci Date: 1971-04-30 Impact factor: 5.691

9. Bradykinin-induced coronary chemoreflex in the dog.

Authors: F R Neto; J C Brasil; A Antonio
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1974 Impact factor: 3.000

10. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors: J R Vane
Journal: Nat New Biol Date: 1971-06-23

19 in total

1. Stimulation of prostaglandin E synthesis in cultured human umbilical vein smooth muscle cells.

Authors: R W Alexander; M A Gimbrone
Journal: Proc Natl Acad Sci U S A Date: 1976-05 Impact factor: 11.205

2. Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts.

Authors: B G Etscheid; P H Ko; M L Villereal
Journal: Br J Pharmacol Date: 1991-06 Impact factor: 8.739

9. Effect of phytohemagglutinin-stimulated human lymphocytes on isolated rat atria. Participation of lipoxygenase products of arachidonic acid metabolism.

Authors: L Sterin-Borda; E Borda; S Fink; M M de Bracco
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1983-09 Impact factor: 3.000

10. Effect of alloimmunized thymic cells on isolated mouse atria. Participation of prostaglandins.

Authors: A M Genaro; G A Cremaschi; M E Sales; E S Borda
Journal: Experientia Date: 1983-09-15