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Literature DB >> 10558988

A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum.

X Su¹, M T Ferdig, Y Huang, C Q Huynh, A Liu, J You, J C Wootton, T E Wellems.

Abstract

Genetic investigations of malaria require a genome-wide, high-resolution linkage map of Plasmodium falciparum. A genetic cross was used to construct such a map from 901 markers that fall into 14 inferred linkage groups corresponding to the 14 nuclear chromosomes. Meiotic crossover activity in the genome proved high (17 kilobases per centimorgan) and notably uniform over chromosome length. Gene conversion events and spontaneous microsatellite length changes were evident in the inheritance data. The markers, map, and recombination parameters are facilitating genome sequence assembly, localization of determinants for such traits as virulence and drug resistance, and genetic studies of parasite field populations.

Entities: Disease Species

Mesh：

Substances：
Genetic Markers

Year: 1999 PMID： 10558988 DOI： 10.1126/science.286.5443.1351

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

136 in total

1. Genetic analysis of phenotype in Trypanosoma brucei: a classical approach to potentially complex traits.

Authors: Andy Tait; Dan Masiga; Johnstone Ouma; Annette MacLeod; Juergen Sasse; Sara Melville; Gabbi Lindegard; Anne McIntosh; Mike Turner
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2002-01-29 Impact factor: 6.237

2. Strong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene.

Authors: S D Polley; D J Conway
Journal: Genetics Date: 2001-08 Impact factor: 4.562

3. Evidence for intragenic recombination in Plasmodium falciparum: identification of a novel allele family in block 2 of merozoite surface protein-1: Asembo Bay Area Cohort Project XIV.

Authors: Shannon Takala; OraLee Branch; Ananias A Escalante; Simon Kariuki; John Wootton; Altaf A Lal
Journal: Mol Biochem Parasitol Date: 2002 Nov-Dec Impact factor: 1.759

4. Mosaic organization and heterogeneity in frequency of allelic recombination of the Plasmodium vivax merozoite surface protein-1 locus.

Authors: Chaturong Putaporntip; Somchai Jongwutiwes; Naoko Sakihama; Marcelo U Ferreira; Weon-Gyu Kho; Akira Kaneko; Hiroji Kanbara; Tetsuya Hattori; Kazuyuki Tanabe
Journal: Proc Natl Acad Sci U S A Date: 2002-12-04 Impact factor: 11.205

5. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

Authors: D A Fidock; T Nomura; A K Talley; R A Cooper; S M Dzekunov; M T Ferdig; L M Ursos; A B Sidhu; B Naudé; K W Deitsch; X Z Su; J C Wootton; P D Roepe; T E Wellems
Journal: Mol Cell Date: 2000-10 Impact factor: 17.970

6. The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism.

Authors: Neil Hall; Matthew Berriman; Nicola J Lennard; Barbara R Harris; Christiane Hertz-Fowler; Emmanuelle N Bart-Delabesse; Caroline S Gerrard; Rebecca J Atkin; Andrew J Barron; Sharen Bowman; Sarah P Bray-Allen; Frédéric Bringaud; Louise N Clark; Craig H Corton; Ann Cronin; Robert Davies; Jonathon Doggett; Audrey Fraser; Eric Grüter; Sarah Hall; A David Harper; Mike P Kay; Vanessa Leech; Rebecca Mayes; Claire Price; Michael A Quail; Ester Rabbinowitsch; Christopher Reitter; Kim Rutherford; Jürgen Sasse; Sarah Sharp; Ratna Shownkeen; Annette MacLeod; Sonya Taylor; Alison Tweedie; C Michael R Turner; Andrew Tait; Keith Gull; Bart Barrell; Sara E Melville
Journal: Nucleic Acids Res Date: 2003-08-15 Impact factor: 16.971

A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum.

1. Genetic analysis of phenotype in Trypanosoma brucei: a classical approach to potentially complex traits.

2. Strong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene.

3. Evidence for intragenic recombination in Plasmodium falciparum: identification of a novel allele family in block 2 of merozoite surface protein-1: Asembo Bay Area Cohort Project XIV.

4. Mosaic organization and heterogeneity in frequency of allelic recombination of the Plasmodium vivax merozoite surface protein-1 locus.

5. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

6. The DNA sequence of chromosome I of an African trypanosome: gene content, chromosome organisation, recombination and polymorphism.

7. Variable numbers of tandem repeats in Plasmodium falciparum genes.

8. Profile of Thomas E. Wellems.

9. Genetic predisposition favors the acquisition of stable artemisinin resistance in malaria parasites.

Review 10. How can we identify parasite genes that underlie antimalarial drug resistance?