| Literature DB >> 10558961 |
S Frey1, R Dagan, Y Ashur, X Q Chen, J Ibarra, H Kollaritsch, M H Mazur, G A Poland, K Reisinger, E Walter, P Van Damme, J H Braconier, I Uhnoo, M Wahl, M M Blatter, D Clements, D Greenberg, R M Jacobson, S R Norrby, M Rowe, D Shouval, S S Simmons, J van Hattum, S Wennerholm, J O Gress.
Abstract
A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.Entities:
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Year: 1999 PMID： 10558961 DOI： 10.1086/315119
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226