Literature DB >> 10557039

The role of homeobox genes in normal hematopoiesis and hematological malignancies.

J van Oostveen1, J Bijl, F Raaphorst, J Walboomers, C Meijer.   

Abstract

In the last decade it has become clear that homeobox containing genes (HOX genes) not only play a significant role in regulating body formation, but in addition, they are contributing to organization and regulation of hematopoiesis. Modern molecular technologies showed that deregulated expression or disruption of Hox genes can lead to altered characteristics of blood cells or disturbance of blood cell development. In this paper we review the role of HOX proteins in hematopoiesis and leukemogenesis and speculate about their possible target genes and involvement in lymphomagenesis.

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Year:  1999        PMID： 10557039     DOI： 10.1038/sj.leu.2401562

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  34 in total

1.  A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells.

Authors:  H Naora; Y Q Yang; F J Montz; J D Seidman; R J Kurman; R B Roden
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

2.  Sustained expression of homeobox D10 inhibits angiogenesis.

Authors:  Connie Myers; Aubri Charboneau; Irene Cheung; Douglas Hanks; Nancy Boudreau
Journal:  Am J Pathol       Date:  2002-12       Impact factor: 4.307

Review 3.  Role of homeobox genes in normal mammary gland development and breast tumorigenesis.

Authors:  Hexin Chen; Saraswati Sukumar
Journal:  J Mammary Gland Biol Neoplasia       Date:  2003-04       Impact factor: 2.673

4.  HemoPDB: Hematopoiesis Promoter Database, an information resource of transcriptional regulation in blood cell development.

Authors:  Twyla T Pohar; Hao Sun; Ramana V Davuluri
Journal:  Nucleic Acids Res       Date:  2004-01-01       Impact factor: 16.971

5.  Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression.

Authors:  Davide Gabellini; Ivan N Colaluca; Hartmut C Vodermaier; Giuseppe Biamonti; Mauro Giacca; Arturo Falaschi; Silvano Riva; Fiorenzo A Peverali
Journal:  EMBO J       Date:  2003-07-15       Impact factor: 11.598

6.  Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis.

Authors:  Elena Levantini; Alessandra Giorgetti; Francesco Cerisoli; Elisabetta Traggiai; Alessandra Guidi; Richard Martin; Dario Acampora; Peter D Aplan; Gordon Keller; Antonio Simeone; Norman N Iscove; Trang Hoang; Maria Cristina Magli
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-21       Impact factor: 11.205

7.  Adaptive evolution of HoxA-11 and HoxA-13 at the origin of the uterus in mammals.

Authors:  Vincent J Lynch; Jutta J Roth; Kazuhiko Takahashi; Casey W Dunn; Daisuke F Nonaka; Geffrey F Stopper; Günter P Wagner
Journal:  Proc Biol Sci       Date:  2004-11-07       Impact factor: 5.349

8.  Analysis of HSC activity and compensatory Hox gene expression profile in Hoxb cluster mutant fetal liver cells.

Authors:  Janet Bijl; Alexander Thompson; Ramiro Ramirez-Solis; Jana Krosl; David G Grier; H Jeffrey Lawrence; Guy Sauvageau
Journal:  Blood       Date:  2005-12-08       Impact factor: 22.113

Review 9.  Hox genes and their candidate downstream targets in the developing central nervous system.

Authors:  Z N Akin; A J Nazarali
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

10.  Thrombopoietin, flt3-ligand and c-kit-ligand modulate HOX gene expression in expanding cord blood CD133 cells.

Authors:  C P McGuckin; N Forraz; R Pettengell; A Thompson
Journal:  Cell Prolif       Date:  2004-08       Impact factor: 6.831
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