Literature DB >> 10556527

Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells.

G Hong1, L M Baudhuin, Y Xu.   

Abstract

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule. It stimulates the growth of some cells, but inhibits the growth of others. In this study, we describe the detection of sub-microM to microM concentrations of S1P in the ascitic fluids of patients with ovarian cancer. In ovarian cancer cells cultured in vitro, S1P exhibited a dual effect on growth and/or survival. S1P (10 microM) induced cell death when cells were in suspension but stimulated cell growth when cells were attached. The calcium-dependent induction of cell death by S1P is apparently associated with its inhibitory effect on cell attachment and cell adhesion. S1P (10-30 microM) also induced calcium-dependent cell-cell aggregation.

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Year:  1999        PMID： 10556527     DOI： 10.1016/s0014-5793(99)01400-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  27 in total

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2.  Sphingosine 1-phosphate receptor expression profile and regulation of migration in human thyroid cancer cells.

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Journal:  World J Gastroenterol       Date:  2010-04-21       Impact factor: 5.742

4.  Toward an integrative analysis of the tumor microenvironment in ovarian epithelial carcinoma.

Authors:  Ryan N Serio
Journal:  Cancer Microenviron       Date:  2011-11-23

5.  Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.

Authors:  James W Antoon; Martin D White; William D Meacham; Evelyn M Slaughter; Shannon E Muir; Steven Elliott; Lyndsay V Rhodes; Hasina B Ashe; Thomas E Wiese; Charles D Smith; Matthew E Burow; Barbara S Beckman
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Review 6.  Targeting SphK1 as a new strategy against cancer.

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7.  LPPR4 promotes peritoneal metastasis via Sp1/integrin α/FAK signaling in gastric cancer.

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8.  Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor.

Authors:  Mitsu Hashimoto; Xingqi Wang; Lijun Mao; Tetsu Kobayashi; Shin Kawasaki; Naoyoshi Mori; Myron L Toews; Hui Jung Kim; D Roselyn Cerutis; Xiangde Liu; Stephen I Rennard
Journal:  Am J Respir Cell Mol Biol       Date:  2008-03-26       Impact factor: 6.914

9.  Local effects of the sphingosine 1-phosphate on prostaglandin F2alpha-induced luteolysis in the pregnant rat.

Authors:  Fatima Hernandez; Marina C Peluffo; Diana Bas; Richard L Stouffer; Marta Tesone
Journal:  Mol Reprod Dev       Date:  2009-12       Impact factor: 2.609

10.  Effects of sphingosine 1-phosphate on excitation-contraction coupling in mammalian skeletal muscle.

Authors:  Chiara Bencini; Roberta Squecco; Claudia Piperio; Lucia Formigli; Elisabetta Meacci; Daniele Nosi; Bruno Tiribilli; Massimo Vassalli; Franco Quercioli; Paola Bruni; Sandra Zecchi Orlandini; Fabio Francini
Journal:  J Muscle Res Cell Motil       Date:  2003       Impact factor: 2.698
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