[Cadmium concentrations in hair, urine and blood among residents in a cadmium-polluted area, Nagasaki, Japan: a 18-year follow-up after soil replacement].

In 1981, the soil of cadmium (Cd)-polluted rice fields was replaced with new soil in Kashine, a Cd-polluted district located on Tsushima Island, Nagasaki Prefecture, Japan. Consequently, the average dietary Cd intake among the inhabitants decreased from 215 micrograms/day in 1969 to 106 micrograms/day in 1983. The authors investigated the health status of Kashine inhabitants before and after the reduction of Cd intake. Concentrations of beta 2-microglobulin in urine (U-beta 2-mg) and Cd in urine (U-Cd), hair (H-Cd) and blood (B-Cd) were measured on 35 inhabitants in 1979 and 1996. The geometric mean of U-beta 2-mg concentration for 9 subjects with U-beta 2-mg levels > or = 1,000 micrograms/g creatinine (microgram/g cr) in 1979 increased by approximately 2.5-fold in 1996. Meanwhile there was little change in the geometric mean for 26 subjects with U-beta 2-mg levels < 1,000 micrograms/g cr in 1996. It was concluded that renal tubular dysfunction among Cd-exposed inhabitants was irreversible and progressive, even after dietary Cd intake decreased. The geometric mean of U-Cd concentration decreased significantly from 11.0 micrograms/g cr in 1979 to 6.3 micrograms/g cr in 1996. The decrease in U-Cd concentrations was significantly greater among inhabitants with U-beta 2-mg levels > or = 1,000 micrograms/g cr than among those with U-beta 2-mg levels < 1,000 micrograms/g cr (p = 0.03). From these results, it was considered that the level of U-Cd was more decreased by the presence of renal tubular dysfunction. The geometric mean of H-Cd concentration decreased significantly from 109.1 micrograms/kg in 1979 to 55.1 micrograms/kg in 1996. However, it was unclear whether the decrease of H-Cd depended on the decrease of dietary Cd intake, decrease of body burden or both, because U-Cd concentrations also decreased by approximately 43% during this period. H-Cd concentration was weakly and positively correlated with U-Cd (r = 0.38-0.44), an indicator of body burden of Cd. These results suggested that H-Cd concentration was influenced by the body burden of this metal. The geometric mean of B-Cd concentration in 33 inhabitants was 5.7 micrograms/l in 1996. The geometric mean was significantly greater in subjects with initial U-beta 2-mg levels > or = 1,000 micrograms/g cr than in those with U-beta 2-mg levels < 1,000 micrograms/g cr. A close positive correlation was found between B-Cd concentrations and U-Cd (r = 0.70, p < 0.01). It was suggested that the body burden influenced the levels of B-Cd as well as U-Cd, many years after Cd exposure had decreased.