Literature DB >> 1055380

RNA synthesis in isolated brian nuclei after administration of d-lysergic acid diethylamide (LSD) in vivo.

I R Brown.   

Abstract

RNA synthesis in isolated brain nuclei was analyzed 2.5 hr after the intravenous administration of d-lysergic acid diethylamide (LSD) to young rabbits. The drug stimulated transcription by 54% in brain stem nuclei and by 13% in cerebral hemisphere nuclei expressed over saline controls. Both nucleoplasmic and nucleolar RNA synthesis were increased. The main activity in the isolated nuclei assay was due to nucleoplasmic RNA polymerase, since alpha-amanitin reduced synthesis by over 70% in either drug or control treatments.

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Year:  1975        PMID： 1055380      PMCID： PMC432415          DOI： 10.1073/pnas.72.3.837

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

1.  Ribosomal RNA synthesis in isolated nuclei.

Authors:  R H Reeder; R G Roeder
Journal:  J Mol Biol       Date:  1972-06-28       Impact factor: 5.469

2.  Studies on RNA synthesis in two populations of nuclei from the mammalian cerebral cortex.

Authors:  R J Thompson
Journal:  J Neurochem       Date:  1973-07       Impact factor: 5.372

3.  Studies by DNA-RNA hybridization of transcriptional diversity in human brain.

Authors:  L Grouse; G A Omenn; B J McCarthy
Journal:  J Neurochem       Date:  1973-04       Impact factor: 5.372

4.  Transcription of nonrepeated DNA during mouse and rabbit development.

Authors:  I R Brown; R B Church
Journal:  Dev Biol       Date:  1972-09       Impact factor: 3.582

5.  Maturation-dependent events related to DNA-dependent RNA synthesis in intact mouse brain nuclei.

Authors:  S P Banks; T C Johnson
Journal:  Brain Res       Date:  1972-06-08       Impact factor: 3.252

6.  RNA transcription from nonrepetitive DNA in the mouse.

Authors:  I R Brown; R B Church
Journal:  Biochem Biophys Res Commun       Date:  1971-03-05       Impact factor: 3.575

7.  Hybridization of ribonucleic acid with unique sequences of mouse deoxyribonucleic acid.

Authors:  L Grouse; M D Chilton; B J McCarthy
Journal:  Biochemistry       Date:  1972-02-29       Impact factor: 3.162

8.  Transcription of nonrepeated DNA in mouse brain.

Authors:  W E Hahn; C D Laird
Journal:  Science       Date:  1971-07-09       Impact factor: 47.728

9.  Synthesis of RNA-polyadenylic acid by isolated brain nuclei.

Authors:  S P Banks; T C Johnson
Journal:  Science       Date:  1973-09-14       Impact factor: 47.728
  9 in total
  5 in total

1.  Developmental changes in DNAse I digestibility and RNA template activity of neuronal nuclei relative to the postnatal appearance of a short DNA repeat length.

Authors:  P D Greenwood; I R Brown
Journal:  Neurochem Res       Date:  1982-08       Impact factor: 3.996

2.  Analysis of putative high-mobility-group (HMG) proteins in neuronal and glial nuclei from rabbit brain.

Authors:  P Greenwood; J C Silver; I R Brown
Journal:  Neurochem Res       Date:  1981-06       Impact factor: 3.996

3.  Developmental changes in chromatin organization in rat cerebral hemisphere neurons and analysis of DNA reassociation kinetics.

Authors:  P D Greenwood; J J Heikkila; I R Brown
Journal:  Neurochem Res       Date:  1982-05       Impact factor: 3.996

4.  Correlated changes in neuronal cerebral rat brain RNA synthesis and hypo- and hypermotoric disorders induced by 6-aminonicotinamide (6-AN).

Authors:  E Knoll-Köhler; F Wojnorowicz; H J Sarkander
Journal:  Exp Brain Res       Date:  1980-01       Impact factor: 1.972

5.  The insensitivity of mushroom nuclear RNA polymerase activity to inhibition by amatoxins.

Authors:  P A Horgen; A C Vaisius; J F Ammirati
Journal:  Arch Microbiol       Date:  1978-09-01       Impact factor: 2.552
  5 in total

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