Literature DB >> 10553718

Molecular modelling of CYP4A subfamily members based on sequence homology with CYP102.

D F Lewis1, B G Lake.   

Abstract

1. Homology modelling of various members of the CYP4A subfamily based on the CYP102 template structure is reported. 2. The binding interactions of specific substrates to the CYP4A forms from rat (CYP4A1), human (CYP4A11) and rabbit (CYP4A4) are shown to be consistent with experimental evidence regarding regioselectivity of metabolism. 3. The differences in substrate specificity between CYP4A1, CYP4A11 and CYP4A4 towards fatty acids and prostaglandins respectively are rationalized in terms of variations in active site amino residues.

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Year:  1999        PMID： 10553718     DOI： 10.1080/004982599238227

Source DB:  PubMed          Journal:  Xenobiotica        ISSN： 0049-8254            Impact factor:   1.908


  4 in total

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Authors:  Amanda L Johnson; Katheryne Z Edson; Rheem A Totah; Allan E Rettie
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2.  Quantitative structure-activity relationships (QSARs) within the cytochrome P450 system: QSARs describing substrate binding, inhibition and induction of P450s.

Authors:  David F V Lewis
Journal:  Inflammopharmacology       Date:  2003       Impact factor: 4.473

3.  Evaluation of drug-drug interaction of lusutrombopag, a thrombopoietin receptor agonist, via metabolic enzymes and transporters.

Authors:  Takayuki Katsube; Yuji Inoue; Takahiro Fukuhara; Takeshi Kano; Toshihiro Wajima
Journal:  Eur J Clin Pharmacol       Date:  2020-07-14       Impact factor: 2.953

4.  Xanthates As Useful Probes for Testing the Active Sites of Cytochromes P450 4A11 and 2E1.

Authors:  Tsveta Stoyanova; Iglika Lessigiarska; Momir Mikov; Ilza Pajeva; Stanislav Yanev
Journal:  Front Pharmacol       Date:  2017-09-22       Impact factor: 5.810
  4 in total

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