D Jarvis1, S Chinn, C Luczynska, P Burney. 1. Department of Public Health Sciences, Guy's King's and St Thomas' School of Medicine, Kings College, Guy's Hospital, London.
Abstract
BACKGROUND: Smoking is a risk factor for sensitization to some occupational allergens, but its association with sensitization to common environmental allergens remains unclear. OBJECTIVE: We sought to determine the association of smoking with total IgE levels and with sensitization to 3 common environmental allergens in data from the European Community Respiratory Health Survey. METHODS: A detailed smoking history and blood sample for determination of serum total IgE and specific IgE levels to house dust mite, grass, and cat allergens was obtained from 13,002 randomly selected young adults living in the areas served by 34 centers in 14 countries. Associations with smoking status and amount smoked were determined. Because there was evidence of heterogeneity between centers in the association of age, sex, and smoking with sensitization, odds ratios (ORs) were determined for each center and combined by using random-effects meta-analysis. RESULTS: Compared with lifetime nonsmokers, current smokers were at an increased risk of sensitization to house dust mite allergen (OR, 1.13; 95% confidence interval [CI], 1.02-1.26) but a decreased risk of sensitization to grass (OR, 0.76; 95% CI, 0.67-0.88) and cat allergens (OR, 0.69; 95% CI, 0.59-0.80). Exclusion of those with symptoms suggestive of current asthma strengthened the association of smoking with sensitization to house dust mite allergen (OR, 1.29; 95% CI, 1.11-1. 50). The geometric mean total IgE level was higher in smokers and was higher among those who currently smoked the most compared with those who smoked less than 5 cigarettes per day. CONCLUSION: The association between smoking and sensitization to common environmental allergens is different for different allergens.
BACKGROUND: Smoking is a risk factor for sensitization to some occupational allergens, but its association with sensitization to common environmental allergens remains unclear. OBJECTIVE: We sought to determine the association of smoking with total IgE levels and with sensitization to 3 common environmental allergens in data from the European Community Respiratory Health Survey. METHODS: A detailed smoking history and blood sample for determination of serum total IgE and specific IgE levels to house dust mite, grass, and cat allergens was obtained from 13,002 randomly selected young adults living in the areas served by 34 centers in 14 countries. Associations with smoking status and amount smoked were determined. Because there was evidence of heterogeneity between centers in the association of age, sex, and smoking with sensitization, odds ratios (ORs) were determined for each center and combined by using random-effects meta-analysis. RESULTS: Compared with lifetime nonsmokers, current smokers were at an increased risk of sensitization to house dust mite allergen (OR, 1.13; 95% confidence interval [CI], 1.02-1.26) but a decreased risk of sensitization to grass (OR, 0.76; 95% CI, 0.67-0.88) and cat allergens (OR, 0.69; 95% CI, 0.59-0.80). Exclusion of those with symptoms suggestive of current asthma strengthened the association of smoking with sensitization to house dust mite allergen (OR, 1.29; 95% CI, 1.11-1. 50). The geometric mean total IgE level was higher in smokers and was higher among those who currently smoked the most compared with those who smoked less than 5 cigarettes per day. CONCLUSION: The association between smoking and sensitization to common environmental allergens is different for different allergens.
Authors: Neerad C Mishra; Jules Rir-sima-ah; R Thomas Boyd; Shashi P Singh; Sravanthi Gundavarapu; Raymond J Langley; Seddigheh Razani-Boroujerdi; Mohan L Sopori Journal: J Immunol Date: 2010-05-26 Impact factor: 5.422
Authors: Wendy Cozen; David Diaz-Sanchez; W James Gauderman; John Zadnick; Myles G Cockburn; Parkash S Gill; Rizwan Masood; Ann S Hamilton; Minna Jyrala; Thomas M Mack Journal: J Clin Immunol Date: 2004-11 Impact factor: 8.317
Authors: Thomas H Thatcher; Randi P Benson; Richard P Phipps; Patricia J Sime Journal: Am J Physiol Lung Cell Mol Physiol Date: 2008-06-20 Impact factor: 5.464
Authors: Suzanne L Havstad; Christine Cole Johnson; Edward M Zoratti; Jerel M Ezell; Kimberly Woodcroft; Dennis R Ownby; Ganesa Wegienka Journal: Respirology Date: 2012-10 Impact factor: 6.424
Authors: S Weidinger; N Klopp; S Wagenpfeil; L Rümmler; M Schedel; M Kabesch; T Schäfer; U Darsow; T Jakob; H Behrendt; H E Wichmann; J Ring; T Illig Journal: J Med Genet Date: 2004-09 Impact factor: 6.318
Authors: Peter J Gergen; Samuel J Arbes; Agustin Calatroni; Herman E Mitchell; Darryl C Zeldin Journal: J Allergy Clin Immunol Date: 2009-08-03 Impact factor: 10.793
Authors: Arthur L Penn; Rodney L Rouse; David W Horohov; Michael T Kearney; Daniel B Paulsen; Larry Lomax Journal: Environ Health Perspect Date: 2007-01-04 Impact factor: 9.031