Literature DB >> 10549712

Structural characterization of low molecular weight heparins.

B Casu1, G Torri.   

Abstract

Low molecular weight heparins (LMWHs) obtained by different depolymerization processes can be distinguished from each other by characteristic end-residues, which are easily identified and quantified by nuclear-magnetic-resonance (NMR) spectroscopy. NMR spectroscopy characterizes major sulfation patterns as well as minor sequences such as the antithrombin-binding sequence and the linkage region of LMWHs. Artifacts associated with base-induced modifications such as the formation of iduronic acid epoxide and aziridine derivatives of N-sulfoglucosamine residues can also be detected. The influence of these modifications on the binding of heparins and LMWHs to proteins other than antithrombin are discussed.

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Year:  1999        PMID： 10549712

Source DB:  PubMed          Journal:  Semin Thromb Hemost        ISSN： 0094-6176            Impact factor:   4.180


  9 in total

1.  Identification of a novel structure in heparin generated by potassium permanganate oxidation.

Authors:  Daniela Beccati; Sucharita Roy; Fei Yu; Nur Sibel Gunay; Ishan Capila; Miroslaw Lech; Robert J Linhardt; Ganesh Venkataraman
Journal:  Carbohydr Polym       Date:  2010-10-15       Impact factor: 9.381

2.  Antithrombin-binding oligosaccharides: structural diversities in a unique function?

Authors:  Marco Guerrini; Pierre A J Mourier; Giangiacomo Torri; Christian Viskov
Journal:  Glycoconj J       Date:  2014-10       Impact factor: 2.916

3.  Monitoring of heparin and its low-molecular-weight analogs by silicon field effect.

Authors:  Nebojsa M Milovic; Jonathan R Behr; Michel Godin; Chih-Sheng Johnson Hou; Kristofor R Payer; Aarthi Chandrasekaran; Peter R Russo; Ram Sasisekharan; Scott R Manalis
Journal:  Proc Natl Acad Sci U S A       Date:  2006-08-28       Impact factor: 11.205

4.  Differentiating chondroitin sulfate glycosaminoglycans using collision-induced dissociation; uronic acid cross-ring diagnostic fragments in a single stage of tandem mass spectrometry.

Authors:  Muchena J Kailemia; Anish B Patel; Dane T Johnson; Lingyun Li; Robert J Linhardt; I Jonathan Amster
Journal:  Eur J Mass Spectrom (Chichester)       Date:  2015       Impact factor: 1.067

5.  Antithrombin-binding octasaccharides and role of extensions of the active pentasaccharide sequence in the specificity and strength of interaction. Evidence for very high affinity induced by an unusual glucuronic acid residue.

Authors:  Marco Guerrini; Sara Guglieri; Benito Casu; Giangiacomo Torri; Pierre Mourier; Christian Boudier; Christian Viskov
Journal:  J Biol Chem       Date:  2008-07-17       Impact factor: 5.157

6.  Rational design of low-molecular weight heparins with improved in vivo activity.

Authors:  Mallik Sundaram; Yiwei Qi; Zachary Shriver; Dongfang Liu; Ganlin Zhao; Ganesh Venkataraman; Robert Langer; Ram Sasisekharan
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-13       Impact factor: 11.205

Review 7.  "In Less than No Time": Feasibility of Rotational Thromboelastometry to Detect Anticoagulant Drugs Activity and to Guide Reversal Therapy.

Authors:  Vittorio Pavoni; Lara Gianesello; Duccio Conti; Piercarlo Ballo; Pietro Dattolo; Domenico Prisco; Klaus Görlinger
Journal:  J Clin Med       Date:  2022-03-04       Impact factor: 4.241

8.  Update on the safety and bioequivalence of biosimilars - focus on enoxaparin.

Authors:  Walter Jeske; Jeanine M Walenga; Debra Hoppensteadt; Jawed Fareed
Journal:  Drug Healthc Patient Saf       Date:  2013-06-10

9.  Characterization of anticoagulant heparinoids by immunoprofiling.

Authors:  Tessa J Wijnhoven; Els M van de Westerlo; Nicole C Smits; Joost F Lensen; Angelique L Rops; Johan van der Vlag; Jo H Berden; Lambert P van den Heuvel; Toin H van Kuppevelt
Journal:  Glycoconj J       Date:  2007-10-02       Impact factor: 2.916
  9 in total

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