Literature DB >> 10549582

HIV integrase inhibitory activity of Agastache rugosa.

H K Kim1, H K Lee, C G Shin, H Huh.   

Abstract

We have been screening anti-HIV integrase compounds from Korean medicinal plants by using an in vitro assay system which is mainly composed of recombinant human immunodeficiency virus type 1 integrase and radiolabeled oligonucleotides. From the above screening, the aqueous methanolic extract of the roots of Agastache rugosa exhibited a significant activity. Bioactivity-guided chromatographic fractionation of the methanolic extract resulted in the isolation of rosmarinic acid. The structure of the compound was determined by spectroscopic data and by the comparison with the reported values. The IC50 of the rosmarinic acid was approximately 10 microg/ml against HIV integrase.

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Year:  1999        PMID： 10549582     DOI： 10.1007/bf02979163

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  12 in total

1.  N-doped carbon nanodots@UiO-66-NH2 as novel nanoparticles for releasing of the bioactive drug, rosmarinic acid and fluorescence imaging.

Authors:  Khalil Tabatabaeian; Masoomeh Simayee; Abdollah Fallah-Shojaie; Farhad Mashayekhi
Journal:  Daru       Date:  2019-06-08       Impact factor: 3.117

2.  Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L.

Authors:  ChoonSeok Oh; Jason Price; Melinda A Brindley; Mark P Widrlechner; Luping Qu; Joe-Ann McCoy; Patricia Murphy; Cathy Hauck; Wendy Maury
Journal:  Virol J       Date:  2011-04-23       Impact factor: 4.099

3.  Chemical constituents and coagulation activity of Agastache rugosa.

Authors:  Pengran Cao; Pingyao Xie; Xuebiao Wang; Jinmei Wang; Jinfeng Wei; Wen-Yi Kang
Journal:  BMC Complement Altern Med       Date:  2017-02-06       Impact factor: 3.659

4.  Microscopic identification and in vitro activity of Agastache rugosa (Fisch. et Mey) from Xinjiang, China.

Authors:  Haiyan Gong; Shaoyu Li; Lijuan He; Rena Kasimu
Journal:  BMC Complement Altern Med       Date:  2017-02-07       Impact factor: 3.659

5.  Inhibition of lentivirus replication by aqueous extracts of Prunella vulgaris.

Authors:  Melinda A Brindley; Mark P Widrlechner; Joe-Ann McCoy; Patricia Murphy; Cathy Hauck; Ludmila Rizshsky; Basil Nikolau; Wendy Maury
Journal:  Virol J       Date:  2009-01-20       Impact factor: 4.099

Review 6.  Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae).

Authors:  Sylwia Zielińska; Adam Matkowski
Journal:  Phytochem Rev       Date:  2014-04-03       Impact factor: 5.374

7.  Antimicrobial, antibiofilm and antitumor activities of essential oil of Agastache rugosa from Xinjiang, China.

Authors:  Gong Haiyan; He Lijuan; Li Shaoyu; Zhang Chen; Muhammad Aqeel Ashraf
Journal:  Saudi J Biol Sci       Date:  2016-03-19       Impact factor: 4.219

Review 8.  Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.

Authors:  Bahare Salehi; Nanjangud V Anil Kumar; Bilge Şener; Mehdi Sharifi-Rad; Mehtap Kılıç; Gail B Mahady; Sanja Vlaisavljevic; Marcello Iriti; Farzad Kobarfard; William N Setzer; Seyed Abdulmajid Ayatollahi; Athar Ata; Javad Sharifi-Rad
Journal:  Int J Mol Sci       Date:  2018-05-14       Impact factor: 5.923

Review 9.  Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules.

Authors:  Syam Mohan; Manal Mohamed Elhassan Taha; Hafiz A Makeen; Hassan A Alhazmi; Mohammed Al Bratty; Shahnaz Sultana; Waquar Ahsan; Asim Najmi; Asaad Khalid
Journal:  Molecules       Date:  2020-10-22       Impact factor: 4.411

10.  Rosmarinic acid exhibits broad anti-enterovirus A71 activity by inhibiting the interaction between the five-fold axis of capsid VP1 and cognate sulfated receptors.

Authors:  Chung-Fan Hsieh; Jia-Rong Jheng; Guan-Hua Lin; Yu-Li Chen; Jin-Yuan Ho; Chien-Jou Liu; Kuei-Yang Hsu; Yuan-Siao Chen; Yoke Fun Chan; Hui-Ming Yu; Pei-Wen Hsieh; Jyh-Haur Chern; Jim-Tong Horng
Journal:  Emerg Microbes Infect       Date:  2020-12       Impact factor: 7.163
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