Literature DB >> 10549580

2- or 6-(1-azidoalkyl)-5,8-dimethoxy-1,4-naphthoquinone: synthesis, evaluation of cytotoxic activity, antitumor activity and inhibitory effect on DNA topoisomerase-I.

G H Chae1, G Y Song, Y Kim, H Cho, D E Sok, B Z Ahn.   

Abstract

6-(1-azidoalkyl)-DMNQ derivatives compared to 2-(1-azidoalkyl)-DMNQ isomers, exhibited higher cytotoxic activity against L1210 mouse leukemia cells and stronger inhibition of DNA topoisomerase-I (TOPO-I), suggesting involvement of steric hindrance. However, similar antitumor activity against mice bearing S-180 cell was shown by 2- and 6-(1-azidoalkyl)-DMNQ derivatives.

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Year:  1999        PMID： 10549580     DOI： 10.1007/bf02979161

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  2 in total

1.  Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain.

Authors:  Duk-Joong Kim; Chang-Ki Choi; Chan-Soo Lee; Mee-Hee Park; Xizhe Tian; Nam Doo Kim; Kee-In Lee; Joong-Kwon Choi; Jin Hee Ahn; Eun-Young Shin; Injae Shin; Eung-Gook Kim
Journal:  Exp Mol Med       Date:  2016-04-29       Impact factor: 8.718

Review 2.  The diverse mechanisms and anticancer potential of naphthoquinones.

Authors:  Carolina Escardó Pereyra; Rafael Ferreira Dantas; Sabrina Baptista Ferreira; Luciano Pinho Gomes; Floriano Paes Silva-Jr
Journal:  Cancer Cell Int       Date:  2019-08-02       Impact factor: 5.722
  2 in total

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