Hematogenous dissemination of ingested polyvinyl chloride particles.

Persorption of large, hard, insoluble, solid particles in micrometer size range is observed with regularity. It is a normal biological effect on the food passage through the intestine. Persorbability of particles is determined by the size of the particles and by their consistency and hardness. PVC particles in micrometer size range are very suitable as models to study persorbability in animals and the hematogenous dissemination of PVC particles. After oral administration of PVC particles to animals, many PVC particles can be found in the blood. Through the bloodsteam they are disseminated in all organs, where individual particles can be found for a long time later.