Literature DB >> 10549282

Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling.

Y Sun1, X Liu, E N Eaton, W S Lane, H F Lodish, R A Weinberg.   

Abstract

TGF-beta treatment of cells induces a variety of physiologic responses, including growth inhibition, differentiation, and induction of apoptosis. TGF-beta induces phosphorylation and nuclear translocation of Smad3. We describe here the association of Smad3 with the nuclear protooncogene protein Ski in response to the activation of TGF-beta signaling. Association with Ski represses transcriptional activation by Smad3, and overexpression of Ski renders cells resistant to the growth-inhibitory effects of TGF-beta. The transcriptional repression as well as the growth resistance to TGF-beta by overexpression of Ski can be overcome by overexpression of Smad3. These results demonstrate that Ski is a novel component of the TGF-beta signaling pathway and shed light on the mechanism of action of the Ski oncoprotein.

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Year:  1999        PMID： 10549282     DOI： 10.1016/s1097-2765(00)80201-4

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  68 in total

1.  Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells.

Authors:  W Wang; F V Mariani; R M Harland; K Luo
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-19       Impact factor: 11.205

Review 2.  Transcriptional control by the TGF-beta/Smad signaling system.

Authors:  J Massagué; D Wotton
Journal:  EMBO J       Date:  2000-04-17       Impact factor: 11.598

3.  Ski interacts with the evolutionarily conserved SNW domain of Skip.

Authors:  T Prathapam; C Kühne; M Hayman; L Banks
Journal:  Nucleic Acids Res       Date:  2001-09-01       Impact factor: 16.971

4.  Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.

Authors:  S L Stroschein; S Bonni; J L Wrana; K Luo
Journal:  Genes Dev       Date:  2001-11-01       Impact factor: 11.361

5.  TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation.

Authors:  Taisuke Kajino; Emily Omori; Shunsuke Ishii; Kunihiro Matsumoto; Jun Ninomiya-Tsuji
Journal:  J Biol Chem       Date:  2007-02-02       Impact factor: 5.157

6.  Ski can negatively regulates macrophage differentiation through its interaction with PU.1.

Authors:  N Ueki; L Zhang; M J Hayman; M J Haymann
Journal:  Oncogene       Date:  2007-07-09       Impact factor: 9.867

Review 7.  TGF-β signaling in C. elegans.

Authors:  Tina L Gumienny; Cathy Savage-Dunn
Journal:  WormBook       Date:  2013-07-10

8.  Ski protein levels increase during in vitro progression of HPV16-immortalized human keratinocytes and in cervical cancer.

Authors:  Yi Chen; Lucia Pirisi; Kim E Creek
Journal:  Virology       Date:  2013-06-27       Impact factor: 3.616

9.  Dual role of SnoN in mammalian tumorigenesis.

Authors:  Qingwei Zhu; Ariel R Krakowski; Elizabeth E Dunham; Long Wang; Abhik Bandyopadhyay; Rebecca Berdeaux; G Steven Martin; LuZhe Sun; Kunxin Luo
Journal:  Mol Cell Biol       Date:  2006-10-30       Impact factor: 4.272

10.  Differential role of Sloan-Kettering Institute (Ski) protein in Nodal and transforming growth factor-beta (TGF-β)-induced Smad signaling in prostate cancer cells.

Authors:  BaoHan T Vo; Bianca Cody; Yang Cao; Shafiq A Khan
Journal:  Carcinogenesis       Date:  2012-07-27       Impact factor: 4.944
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