Literature DB >> 10548664

Stroke in the very old : clinical presentation and determinants of 3-month functional outcome: A European perspective. European BIOMED Study of Stroke Care Group.

A Di Carlo1, M Lamassa, G Pracucci, A M Basile, G Trefoloni, P Vanni, C D Wolfe, K Tilling, S Ebrahim, D Inzitari.   

Abstract

BACKGROUND AND
PURPOSE: The oldest old represent the fastest-growing segment of the elderly population in developed countries. Knowledge of age-specific aspects of stroke is essential to establish diagnostic and therapeutic pathways and to set up prevention and rehabilitation programs. We sought to evaluate stroke features and functional outcome in patients aged >/=80 years compared with the younger age groups.
METHODS: In a European Union Concerted Action involving 7 countries, 4499 patients hospitalized for first-in-a-lifetime stroke were evaluated for demographics, risk factors, clinical presentation, resource use, and 3-month disability (Barthel Index) and handicap (Rankin Scale).
RESULTS: Overall, 3141 patients (69.8%) were aged <80 years, and 1358 (30.2%) were aged >/=80 years. At baseline, female sex, prestroke institutionalization, and a worse prestroke Rankin score were significantly more frequent in the older patients, as were coma, paralysis, swallowing problems, and urinary incontinence in the acute phase (all P values <0.001). Brain imaging and other diagnostic tools were significantly less used in the older patients. Paralysis, swallowing problems, and incontinence during hospitalization independently predicted 3-month disability or handicap in both groups. For the older patients, prestroke institutionalization proved a further strong and independent determinant of 3-month disability (odds ratio, 2.33; 95% CI, 1.22 to 4.45) and handicap (odds ratio, 7.04; 95% CI, 1.62 to 30. 69).
CONCLUSIONS: In the very old, both medical and sociodemographic factors may significantly influence stroke outcome, showing peculiar characteristics. Knowledge of these determinants may reduce the burden on health systems, improving quality of care.

Entities:  

Mesh:

Year:  1999        PMID: 10548664     DOI: 10.1161/01.str.30.11.2313

Source DB:  PubMed          Journal:  Stroke        ISSN: 0039-2499            Impact factor:   7.914


  47 in total

Review 1.  Thrombolysis, stroke-unit admission and early rehabilitation in elderly patients.

Authors:  Laurent Derex; Norbert Nighoghossian
Journal:  Nat Rev Neurol       Date:  2009-08-04       Impact factor: 42.937

2.  Age differences in clinical characteristics, health care, and outcomes after ischemic stroke in China.

Authors:  Ya-Xian Deng; Yi-Long Wang; Bao-Qin Gao; Chun-Xue Wang; Xing-Quan Zhao; Li-Ping Liu; An-Xin Wang; Yong Zhou; Gai-Fen Liu; Wan-Liang Du; Ning Zhang; Jing Jing; Xia Meng; Jie Xu; Lin-Yu Wang; Yong-Jun Wang
Journal:  CNS Neurosci Ther       Date:  2012-08-20       Impact factor: 5.243

3.  Research priorities for high-quality geriatric emergency care: medication management, screening, and prevention and functional assessment.

Authors:  Christopher R Carpenter; Kennon Heard; Scott Wilber; Adit A Ginde; Kirk Stiffler; Lowell W Gerson; Neal S Wenger; Douglas K Miller
Journal:  Acad Emerg Med       Date:  2011-06       Impact factor: 3.451

4.  Significant variation in mortality and functional outcome after acute ischaemic stroke between Western countries: data from the tinzaparin in acute ischaemic stroke trial (TAIST).

Authors:  L J Gray; N Sprigg; P M W Bath; P Sørensen; E Lindenstrøm; G Boysen; P P De Deyn; P Friis; D Leys; R Marttila; J-E Olsson; D O'Neill; B Ringelstein; J-J van der Sande; A G G Turpie
Journal:  J Neurol Neurosurg Psychiatry       Date:  2005-07-26       Impact factor: 10.154

Review 5.  Ischemic stroke in the elderly: an overview of evidence.

Authors:  Ruo-Li Chen; Joyce S Balami; Margaret M Esiri; Liang-Kung Chen; Alastair M Buchan
Journal:  Nat Rev Neurol       Date:  2010-04-06       Impact factor: 42.937

6.  Prestroke dementia is associated with poor outcomes after reperfusion therapy among elderly stroke patients.

Authors:  Katharina M Busl; Raul G Nogueira; Albert J Yoo; Joshua A Hirsch; Lee H Schwamm; Natalia S Rost
Journal:  J Stroke Cerebrovasc Dis       Date:  2011-12-17       Impact factor: 2.136

7.  Thrombolytic therapy for acute ischaemic stroke in octogenarians: selection by magnetic resonance imaging improves safety but does not improve outcome.

Authors:  P A Ringleb; Ch Schwark; M Köhrmann; S Külkens; E Jüttler; W Hacke; P D Schellinger
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-10-20       Impact factor: 10.154

8.  Ischemic Stroke in the Elderly: Septuagenarians Versus Octogenarians.

Authors:  Birgül Baştan; Sefer Günaydin; Fatma Belgin Balci; Hürtan Acar; Aytül Mutlu; Feriha Özer; Özlem Çokar
Journal:  Noro Psikiyatr Ars       Date:  2016-12-01       Impact factor: 1.339

9.  Atrial fibrillation in patients with ischemic stroke: A population-based study.

Authors:  Sandra Kruchov Thygesen; Lars Frost; Kim A Eagle; Søren Paaske Johnsen
Journal:  Clin Epidemiol       Date:  2009-08-09       Impact factor: 4.790

Review 10.  Safety and efficacy of thrombolysis with intravenous alteplase in older stroke patients.

Authors:  Hakan Sarikaya
Journal:  Drugs Aging       Date:  2013-04       Impact factor: 3.923

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.